1. Cell Cycle/DNA Damage
  2. CDK

BAY-1143572 S-Enantiomer 

Cat. No.: HY-12871C Purity: 94.57% ee.: 99.74%
Handling Instructions

BAY-1143572 S-Enantiomer is a potent and selective CDK9 inhibitor, which inhibits CDK9/CycT1 with an IC50 of 16 nM.

For research use only. We do not sell to patients.

BAY-1143572 S-Enantiomer Chemical Structure

BAY-1143572 S-Enantiomer Chemical Structure

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 605 In-stock
Estimated Time of Arrival: December 31
5 mg USD 550 In-stock
Estimated Time of Arrival: December 31
10 mg USD 850 In-stock
Estimated Time of Arrival: December 31
50 mg   Get quote  
100 mg   Get quote  

* Please select Quantity before adding items.

Other Forms of BAY-1143572 S-Enantiomer:

  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

BAY-1143572 S-Enantiomer is a potent and selective CDK9 inhibitor, which inhibits CDK9/CycT1 with an IC50 of 16 nM.

IC50 & Target

IC50: 16 nM (CDK9/CycT1)[1]

In Vitro

In comparison with BAY 1143572, BAY-1143572 S-Enantiomer reveals very similar in vitro properties, well within the limits of measurement accuracy; however, with multiple batches of BAY-1143572 S-Enantiomer there is a trend toward a slightly lower activity against CDK9 in the biochemical assay (IC50 CDK9/CycT1: 16 nM) and antiproliferative activity against HeLa cells (IC50: 1100 nM) [1].

In Vivo

BAY-1143572 S-Enantiomer exhibits blood/plasma ratios of about 1. Relative to BAY 1143572, BAY-1143572 S-Enantiomer reveals very similar rat PK properties in vivo (CLb: 1.2 L/kg per hour, Vss: 1.2 L/kg, t1/2: 0.6 h, F: 53 %)[1].

Solvent & Solubility
In Vitro: 

DMSO : ≥ 113 mg/mL (291.67 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5811 mL 12.9056 mL 25.8111 mL
5 mM 0.5162 mL 2.5811 mL 5.1622 mL
10 mM 0.2581 mL 1.2906 mL 2.5811 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

387.43

Formula

C₁₈H₁₈FN₅O₂S

SMILES

N=[[email protected]@](CC1=CC(NC2=NC(C3=CC=C(F)C=C3OC)=NC=N2)=CC=C1)(C)=O

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Shipping

Room temperature in continental US; may vary elsewhere

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× = ×
C1   V1   C2   V2

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Product Name:
BAY-1143572 S-Enantiomer
Cat. No.:
HY-12871C
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BAY-1143572 S-Enantiomer

Cat. No.: HY-12871C