1. GPCR/G Protein
    Neuronal Signaling
  2. 5-HT Receptor
  3. Cyclobenzaprine hydrochloride

Cyclobenzaprine hydrochloride (Synonyms: MK130 hydrochloride)

Cat. No.: HY-B0740 Purity: 99.91%
Handling Instructions

Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant.

For research use only. We do not sell to patients.

Cyclobenzaprine hydrochloride Chemical Structure

Cyclobenzaprine hydrochloride Chemical Structure

CAS No. : 6202-23-9

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Solution
10 mM * 1 mL in DMSO USD 72 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 72 In-stock
Estimated Time of Arrival: December 31
Solid
500 mg USD 65 In-stock
Estimated Time of Arrival: December 31
1 g USD 108 In-stock
Estimated Time of Arrival: December 31
5 g USD 436 In-stock
Estimated Time of Arrival: December 31
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50 g   Get quote  

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Other Forms of Cyclobenzaprine hydrochloride:

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Description

Cyclobenzaprine hydrochloride (MK130 hydrochloride) is a skeletal muscle relaxant and a central nervous system (CNS) depressant. Target: 5-HT Receptor 2A Cyclobenzaprine hydrochloride is a skeletal muscle relaxant and a central nervous system (CNS) depressant. Cyclobenzaprine hydrochloride was thought to be an alpha 2-adrenoceptor agonist that reduced muscle tone by decreasing the activity of descending noradrenergic neurons. Cyclobenzaprine hydrochloride reduced the monosynaptic reflex amplitude dose dependently and this effect was not inhibited by the alpha 2-adrenoceptor antagonists idazoxan and yohimbine. Cyclobenzaprine-induced monosynaptic reflex depression was not attenuated by noradrenergic neuronal lesions produced by 6-hydroxydopamine. Cyclobenzaprine hydrochloride is a 5-HT2 receptor antagonist and that its muscle relaxant effect is due to inhibition of serotonergic, not noradrenergic, descending systems in the spinal cord [1]. The inhibitory effects of Cyclobenzaprine hydrochloride on mono- and polysynaptic reflex potentials are due to the inhibition of descending serotonergic systems through 5-HT(2) receptors in the spinal cord [2].

Clinical Trial
Molecular Weight

311.85

Formula

C20H22ClN

CAS No.
SMILES

CN(C)CC/C=C1C2=CC=CC=C2C=CC3=CC=CC=C\13.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (320.67 mM)

DMSO : 50 mg/mL (160.33 mM; Need ultrasonic)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2067 mL 16.0333 mL 32.0667 mL
5 mM 0.6413 mL 3.2067 mL 6.4133 mL
10 mM 0.3207 mL 1.6033 mL 3.2067 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  PBS

    Solubility: 110 mg/mL (352.73 mM); Clear solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (8.02 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (8.02 mM); Clear solution

  • 4.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.02 mM); Clear solution

*All of the co-solvents are available by MCE.
References
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Product Name:
Cyclobenzaprine hydrochloride
Cat. No.:
HY-B0740
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