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DUPA(OtBu)-OH 

Cat. No.: HY-103591
Handling Instructions

DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.

For research use only. We do not sell to patients.

DUPA(OtBu)-OH Chemical Structure

DUPA(OtBu)-OH Chemical Structure

CAS No. : 1026987-94-9

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  • Biological Activity

  • Technical Information

  • Purity & Documentation

  • References

Description

DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.

In Vitro

DUPA(OtBu)-OH (DUPA precursor 17) is a 2-[3-(1,3-dicarboxypropyl)ureido]pentanedioic acid (DUPA) reagent[1]. The targeting ligand DUPA enhances the transport capability and selectivity of Paclitaxel (PTX) to tumor cells via prostate-specific membrane antigen (PSMA) mediated endocytosis. Besides, DUPA is conjugated with PTX via a disulfide bond, which facilitates the rapid and differential drug release in tumor cells[2].

In Vivo

DUPA-targeted Docetaxel (DTX) conjugate with longer spacer has no toxicity in major organs of treated mice[3].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0468 mL 10.2339 mL 20.4679 mL
5 mM 0.4094 mL 2.0468 mL 4.0936 mL
10 mM 0.2047 mL 1.0234 mL 2.0468 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

488.57

Formula

C₂₃H₄₀N₂O₉

CAS No.

1026987-94-9

SMILES

O=C(OC(C)(C)C)CC[[email protected]@H](C(OC(C)(C)C)=O)NC(N[[email protected]](C(OC(C)(C)C)=O)CCC(O)=O)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
DUPA(OtBu)-OH
Cat. No.:
HY-103591
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DUPA(OtBu)-OH

Cat. No.: HY-103591