1-Methyl-L-histidine

Name: 1-Methyl-L-histidine
Brand: MedChemExpress
SKU: HY-W017006
Rating: 4.5 (2 reviews)

Cat. No.: HY-W017006 Purity: 99.92%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

1-Methyl-L-histidine is an objective indicator of meat ingestion and exogenous 3-methylhistidine (3MH) intake.

For research use only. We do not sell to patients.

1-Methyl-L-histidine Chemical Structure

CAS No. : 332-80-9

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in Water ready for reconstitution	USD 66	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in Water	USD 66	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 38	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 60	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 90	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

or Bulk Inquiry

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

Other Forms of 1-Methyl-L-histidine:

1-Methyl-L-histidine-d₃ In-stock

2 Publications Citing Use of MCE 1-Methyl-L-histidine

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•Related Screening Libraries:

•Related Small Molecules:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

1-Methyl-L-histidine is an objective indicator of meat ingestion and exogenous 3-methylhistidine (3MH) intake.

IC₅₀ & Target

Human Endogenous Metabolite

Molecular Weight

169.18

Formula

C₇H₁₁N₃O₂

CAS No.

332-80-9

Appearance

Solid

Color

White to off-white

SMILES

N[C@@H](CC1=CN(C)C=N1)C(O)=O

Structure Classification

Ketones, Aldehydes, Acids

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

H₂O : 125 mg/mL (738.86 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.9109 mL	29.5543 mL	59.1086 mL
5 mM	1.1822 mL	5.9109 mL	11.8217 mL
10 mM	0.5911 mL	2.9554 mL	5.9109 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (591.09 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (271 KB) SDS (0 KB)

COA (246 KB) RP-HPLC (258 KB) MS (70 KB)

Handling Instructions (2659 KB)

References

[1]. Sjölin J, et al. Urinary excretion of 1-methylhistidine: a qualitative indicator of exogenous 3-methylhistidine and intake of meats from various sources. Metabolism. 1987 Dec;36(12):1175-84. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.9109 mL	29.5543 mL	59.1086 mL	147.7716 mL
	5 mM	1.1822 mL	5.9109 mL	11.8217 mL	29.5543 mL
	10 mM	0.5911 mL	2.9554 mL	5.9109 mL	14.7772 mL
	15 mM	0.3941 mL	1.9703 mL	3.9406 mL	9.8514 mL
	20 mM	0.2955 mL	1.4777 mL	2.9554 mL	7.3886 mL
	25 mM	0.2364 mL	1.1822 mL	2.3643 mL	5.9109 mL
	30 mM	0.1970 mL	0.9851 mL	1.9703 mL	4.9257 mL
	40 mM	0.1478 mL	0.7389 mL	1.4777 mL	3.6943 mL
	50 mM	0.1182 mL	0.5911 mL	1.1822 mL	2.9554 mL
	60 mM	0.0985 mL	0.4926 mL	0.9851 mL	2.4629 mL
	80 mM	0.0739 mL	0.3694 mL	0.7389 mL	1.8471 mL
	100 mM	0.0591 mL	0.2955 mL	0.5911 mL	1.4777 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.