Hexaminolevulinate hydrochloride
Based on 1 Customer Validation
Hexaminolevulinate (Hexyl 5-aminolevulinate) hydrochloride, a porphyrin precursor, is a photosensitiser that can be used in photodynamic therapy (PDT) for certain tumor. Hexaminolevulinate hydrochloride can improve the visualisation of bladder tumours.
For research use only. We do not sell to patients.
- Purity: 99.88%
- CAS No.: 140898-91-5
- Formula: C11H22ClNO3
- Molecular Weight:251.75
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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HY-N0305
5-Aminolevulinic acid hydrochloride
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HY-D0711
Indocyanine green
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HY-N0305R
5-Aminolevulinic acid hydrochloride (Standard)
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HY-D0815
Propidium Iodide
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HY-D1028
DiD perchlorate
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HY-D0969
DiO
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HY-116215
2-NBDG
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HY-D0938
CFDA-SE
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HY-D0819
CY5-SE
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HY-D0711R
Indocyanine green (Standard)
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HY-126793
2′,7′-Dichlorofluorescein diacetate
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HY-DY1006
Propidium Iodide (solution)
Biological Activity
Hexaminolevulinate (2.5-100 μM; 4 h in serum-free medium) hydrochloride induces PpIX production in L1210 cell line and pure BM[2].
Hexaminolevulinate (1-100 μM; 4 h in serum-free medium) hydrochloride induces PpIX production in the mixtures of BM with L1210 tumor cells[2].
Hexaminolevulinate (20-100 μM) in combination with increasing doses of blue light illumination from 0 to 120 s results in progressive killing of L1210 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 140898-91-5
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Appearance Solid
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Molecular Weight 251.75
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Formula C11H22ClNO3
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Color White to off-white
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SMILES
O=C(OCCCCCC)CCC(CN)=O.[H]Cl
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Synonyms
Hexyl 5-aminolevulinate hydrochloride; P-1206; 5-Aminolevulinic acid hexyl ester hydrochloride
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvent & Solubility
DMSO : ≥ 100 mg/mL (397.22 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
H2O : 100 mg/mL (397.22 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (268 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
[1]. Witjes JA, et, al. Hexaminolevulinate-guided fluorescence cystoscopy in the diagnosis and follow-up of patients with non-muscle-invasive bladder cancer: review of the evidence and recommendations. Eur Urol. 2010 Apr;57(4):607-14. [Content Brief]
[2]. Čunderlíková B, et, al. Hexaminolevulinate-mediated photodynamic purging of leukemia cells from BM. Bone Marrow Transplant. 2010 Oct;45(10):1553-61. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 3.9722 mL | 19.8610 mL | 39.7219 mL | 99.3049 mL |
| 5 mM | 0.7944 mL | 3.9722 mL | 7.9444 mL | 19.8610 mL | |
| 10 mM | 0.3972 mL | 1.9861 mL | 3.9722 mL | 9.9305 mL | |
| 15 mM | 0.2648 mL | 1.3241 mL | 2.6481 mL | 6.6203 mL | |
| 20 mM | 0.1986 mL | 0.9930 mL | 1.9861 mL | 4.9652 mL | |
| 25 mM | 0.1589 mL | 0.7944 mL | 1.5889 mL | 3.9722 mL | |
| 30 mM | 0.1324 mL | 0.6620 mL | 1.3241 mL | 3.3102 mL | |
| 40 mM | 0.0993 mL | 0.4965 mL | 0.9930 mL | 2.4826 mL | |
| 50 mM | 0.0794 mL | 0.3972 mL | 0.7944 mL | 1.9861 mL | |
| 60 mM | 0.0662 mL | 0.3310 mL | 0.6620 mL | 1.6551 mL | |
| 80 mM | 0.0497 mL | 0.2483 mL | 0.4965 mL | 1.2413 mL | |
| 100 mM | 0.0397 mL | 0.1986 mL | 0.3972 mL | 0.9930 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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