Bcl-W Degrader
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PZ15227
0 ImagesCat. No.: HY-152179CAS No.: 2143464-25-7PZ15227 is a potent and selective Bcl-XL PROTAC degrader with a DC50 of 46 nM, and its Ki values for Bcl-XL, Bcl-2 and Bcl-w are 1.90 nM, 3.52 nM and >1 mM, respectively. PZ15227 recruits Bcl-XL to CRBN, induces polyubiquitination of Bcl-XL and promotes its proteasome-dependent degradation, thereby selectively killing senescent cells that rely on Bcl-XL for survival without causing severe thrombocytopenia. PZ15227 can be used for research related to age-related diseases, aging and renal cancer.
