CRFR1 Antagonist
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R121919
0 ImagesSynonyms: NBI30775R121919 (NBI30775) is a potent and selective CRF1R antagonist with a Ki of 2 to 5 nM. R121919 has antidepressant and anxiolytic effects. R121919 alleviates defensive withdrawal in rats.
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CP 376395
0 ImagesCP 376395 is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist.
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Verucerfont
0 ImagesSynonyms: GSK561679Verucerfont is a corticotropin-releasing factor receptor 1 (CRF1) antagonist with IC50s of ~6.1, >1000 and >1000?nM for CRF1, CRF2, and CRF-BP, respectively.
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CRF1 receptor antagonist-2
0 ImagesCat. No.: HY-182645CAS No.: 441060-02-2CRF1 receptor antagonist-2 is an orally active, blood-brain barrier permeable CRF1 receptor antagonist, with an IC50 of 4 nM in CHO-K1 cell membranes and an IC50 of 7 nM in rat brain cell membranes. CRF1 receptor antagonist-2 exerts anxiolytic effects in swim stress-loaded rats. CRF1 receptor antagonist-2 can be used in studies related to stress-induced anxiety.
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NBI-27914 hydrochloride
0 ImagesCat. No.: HY-103376CAS No.: 1215766-76-9NBI-27914 (hydrochloride) is a selective Corticotropin-Releasing Factor 1 (CRF1) receptor antagonist with a Ki value of 1.7 nM.
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NBI 35965 methanesulfonate
0 ImagesCat. No.: HY-103378CAS No.: 603151-83-3NBI 35965 methanesulfonate is a selective, orally active and brain-penetrant corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki value of 4 nM and a pKi value of 8.5. NBI 35965 methanesulfonate does not inhibit CRF2. NBI 35965 methanesulfonate reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo with pIC50 values of 7.1 and 6.9, respectively. NBI 35965 methanesulfonate shows anxiolytic effects.
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R121919 hydrochloride
0 ImagesCat. No.: HY-115645CAS No.: 195055-66-4Synonyms: NBI30775 hydrochlorideR121919 (NBI30775) hydrochloride is a potent and selective CRF1R antagonist with a Ki of 2 to 5 nM. R121919 hydrochloride has antidepressant and anxiolytic effects. R121919 hydrochloride alleviates defensive withdrawal in rats.
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CP 376395 hydrochloride
0 ImagesCat. No.: HY-103379CAS No.: 1013933-37-3CP 376395 hydrochloride is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist.
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NBI 35965 hydrochloride
0 ImagesCat. No.: HY-110056CAS No.: 1782228-59-4NBI 35965 hydrochloride is a selective, orally active and brain-penetrant corticotropin-releasing factor receptor 1 (CRF1) antagonist with a Ki value of 4 nM and a pKi value of 8.5. NBI 35965 hydrochloride does not inhibit CRF2. NBI 35965 hydrochloride reduces CRF or stress-induced adrenocorticotropic hormone (ACTH) production in vivo with pIC50 values of 7.1 and 6.9, respectively. NBI 35965 hydrochloride shows anxiolytic effects.
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CP 316311
0 ImagesCat. No.: HY-14129CAS No.: 175139-41-0CP 316311 is a potent and selective CRF1 receptor antagonist with an IC50 value of 6.8 nM.
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NBI-34041
0 ImagesCat. No.: HY-14128CAS No.: 268545-87-5Synonyms: SB-723620NBI-34041 (SB-723620) is a selective and orally active nonpeptide CRF1 receptor antagonist with an IC50 of 58.9 nM and a Ki of 4.0 nM for human CRF1 receptor. NBI-34041 has no inhibitory effect on the CRF2 receptor. NBI-34041 can be used for depression and anxiety disorders research.
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NBI-35965
0 ImagesCat. No.: HY-162872CAS No.: 268546-19-6NBI-35965 is an antagonist of corticotropin-releasing factor receptor 1 (CRF-R1). NBI-35965 can be used in nervous system related research.
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