R121919 hydrochloride
Based on 7 publication(s) in Google Scholar
R121919 (NBI30775) hydrochloride is a potent and selective CRF1R antagonist with a Ki of 2 to 5 nM. R121919 hydrochloride has antidepressant and anxiolytic effects. R121919 hydrochloride alleviates defensive withdrawal in rats.
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- CAS No.: 195055-66-4
- Formule: C22H33ClN6
- Masse moléculaire:416.99
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Publications Citing Use of MedChemExpress (MCE) R121919 hydrochloride
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Activité biologique
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CRFR1 2-5 nM (Ki) |
R121919 hydrochloride is a potent small-molecule CRF1 receptor antagonistwith high affinity for the CRF1 receptor and over 1000-fold weaker activity at the CRF2 receptor, CRF-binding protein, or 70 other receptor types[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
R121919 hydrochloride reduces levels of anxiety in mice with a steep dose-response curve[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 195055-66-4
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Masse moléculaire 416.99
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Formule C22H33ClN6
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SMILES
CCCN(CCC)C1=CC(C)=NC2=C(C3=C(C)C=C(N(C)C)N=C3)C(C)=NN12.[H]Cl
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Synonyms
NBI30775 hydrochloride
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (7)
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Journal Impact Factor
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Most Recent
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Nat Commun
Hypothalamus-sympathetic-liver axis mediates the early phase of stress-induced hyperglycemia in the male mice. [Abstract]2024 Oct 5;15(1):8632. PMID: 39366937 -
Sci Adv
Hyperexcitation of ovBNST CRF neurons during stress contributes to female-biased expression of anxiety-like avoidance behaviors. [Abstract]2024 May 10;10(19):eadk7636. PMID: 38728397 -
Ecotoxicol Environ Saf
Asiaticoside ameliorates pyrimethanil-induced autophagy-dependent liver injury by suppressing CRHR1. [Abstract]2025 Dec:308:119482. PMID: 41338089 -
Neuropharmacology
2024 Nov 1:258:110066. PMID: 38986806 -
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bioRxiv
Peripubertal antagonism of corticotropin-releasing factor receptor 1 results in sustained, sex-specific changes in behavioral plasticity and the transcriptomic profile of the amygdala. [Abstract]2024 Aug 15:2024.08.14.607957. PMID: 39185241 -
Pureté et documentation
Références
[1]. Gutman DA, et al. The corticotropin-releasing factor1 receptor antagonist R121919 attenuates the behavioral and endocrine responses to stress. J Pharmacol Exp Ther. 2003 Feb;304(2):874-80. [Content Brief]
[2]. Post A, et al. Identification of molecules potentially involved in mediating the in vivo actions of the corticotropin-releasing hormone receptor 1 antagonist, NBI30775 (R121919). Psychopharmacology (Berl). 2005 Jun;180(1):150-8. [Content Brief]
[3]. Gutman DA, et al. Behavioral effects of the CRF1 recepator antagonist R121919 in rats selectively bred for high and low activity in the swim test. Psychoneuroendocrinology. 2008 Sep;33(8):1093-101. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
R121919 hydrochloride Related Classifications
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