2. GPCR/G Protein
  3. CRFR
  4. CP 376395 hydrochloride

CP 376395 hydrochloride is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist.

For research use only. We do not sell to patients.

CP 376395 hydrochloride Chemical Structure

CP 376395 hydrochloride Chemical Structure

CAS No. : 1013933-37-3

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CP 376395 hydrochloride Related Antibodies

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Description

CP 376395 hydrochloride is a potent, selective, and brain-penetrable Corticotropin releasing factor 1 (CRF1) receptor antagonist[1][2].

IC50 & Target

CRFR1

 

CRFR2

 

In Vitro

CP 376395 fully antagonizes oCRF-stimulated adenylate cyclase activity in rat cerebral cortex and at human CRF1 receptors with an apparent Ki value of 12 nM, indicating antagonist functional activity. It is highly selective for the human CRF1 receptor subtype; affinity for the CRF2 receptor is >10000 nM. It shows affinities greater than 1 µM against 40 neurotransmitter receptor and ion channels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CP 376395 hydrochloride Related Antibodies
In Vivo

CP 376395 (10-20 mg/kg, i.p., Male B6 mice) attenuates H2O and food intake, increases sucrose intake, attenuates EtOH intake but not EtOH preference[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male B6 mice (n=8-9 per group)[2]
Dosage: 0.0, 10.0, or 20.0 mg/kg
Administration: Intraperitoneally
Result: Dose-dependently attenuated intake of H2O and food, with H2O intake affected specifically during the first half of the session.
Molecular Weight

362.94

Formula

C21H31ClN2O
CAS No.
SMILES

CC1=C(OC2=NC(C)=CC(NC(CC)CC)=C2C)C(C)=CC(C)=C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CP 376395 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CP 3763951013933-37-3CP376395CP-376395CRFRCorticotropin-releasing Factor ReceptorCRHRInhibitorinhibitorinhibit

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CP 376395 hydrochloride
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HY-103379
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