2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel
  5. N-type calcium channel Isoform
  6. N-type calcium channel Inhibitor

N-type calcium channel Inhibitor

N-type calcium channel Inhibitors (8):

Cat. No. Product Name Effect Purity
  • HY-N0601
    Ginsenoside Rf
    		Inhibitor 99.48%
    Ginsenoside Rf is a trace component of ginseng root. Ginsenoside Rf inhibits N-type Ca2+ channel.
  • HY-14462
    NP118809
    		Inhibitor 98.79%
    NP118809 is a potent N-type calcium channel blocker, with an IC50 of 0.11 μM; also less potently inhibits L-type calcium channel with an IC50 of 12.2 μM.
  • HY-P5822
    ω-Conotoxin CnVIIA
    		Inhibitor
    ω-Conotoxin CnVIIA, a 27 amino acid neuropeptide toxin, is a N-type calcium current blocker.
  • HY-P5820
    ω-Conotoxin Bu8
    		Inhibitor
    ω-Conotoxin Bu8 is a ω-conotoxin, which consists of 25 amino acid residues and three disulfide bridges. ω-Conotoxin Bu8 selectively and potently inhibits depolarization-activated Ba2+ currents mediated by rat CaV2.2 expressed in HEK293T cells (IC50= 89 nM).
  • HY-132268
    Cav 2.2 blocker 2
    		Inhibitor 98.45%
    Cav 2.2 blocker 2 is a Cav2.2 calcium channel blocker extracted from patent WO2017046581A1, compound 1. Cav 2.2 blocker 2 can reverses hyperalgesia associated with an injury or inflammation in conjunction with the opioid.
  • HY-147638
    MONIRO-1
    		Inhibitor
    MONIRO-1 is a T-type and N-type calcium channel blocker with IC50 values of 34, 3.3, 1.7 and 7.2 µM against hCav2.2, hCav3.1, hCav3.2 and hCav3.3, respectively.
  • HY-147639
    Cav 2.2/3.2 blocker 1
    		Inhibitor
    Cav 2.2/3.2 blocker 1 (Compound 9e) is a neuronal calcium channel blocker with IC50 values of 78 μM and 80 μM against Cav2.2 and Cav3.2, respectively. Cav 2.2/3.2 blocker 1 can penetrate the CNS.
  • HY-U00236
    PD0176078
    		Inhibitor 99.80%
    PD0176078 is a newly found N-type Calcium channel blocker.