GHSR
Growth hormone secretagogue receptor; Ghrelin receptor
GHSR (Growth hormone secretagogue receptor) is a seven transmembrane G protein-coupled receptor with high expression in the anterior pituitary, pancreatic islets, thyroid gland, heart and various regions of the brain. Two types of GHS-R are accepted to be present, GHS-R1a and GHS-R1b.
Ghrelin is a gastric polypeptide displaying strong GH-releasing activity by activation of the GHS-R1a located in the hypothalamus-pituitary axis. GHS-R1a is a G-protein-coupled receptor that, upon the binding of ghrelin or synthetic peptidyl and non-peptidyl ghrelin-mimetic agents known as GHS, preferentially couples to Gq, ultimately leading to increased intracellular calcium content. Beside the potent GH-releasing action, ghrelin and GHS influence food intake, gut motility, sleep, memory and behavior, glucose and lipid metabolism, cardiovascular performances, cell proliferation, immunological responses and reproduction.
GHSR Isoform Specific Products
All Product Categories
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GHSR Related Products (77)
Related Products (77)
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Antibodies (3)
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GHSR Isoform Comparison
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JMV 2959 hydrochloride
0 ImagesCat. No.: HY-U00433ACAS No.: 2448414-54-6JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32±3 nM in LLC-PK1 cells.
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Cortistatin-8
0 ImagesSynonyms: PCFWKTCKCortistatin-8 (CST-8; PCFWKTCK), a neuropeptide, is a GHS-R1a antagonist by counteracting the response of ghrelin on gastric acid secretion. Cortistatin-8 can modulate GH release from somatotroph cells. Cortistatin-8 is a synthetic CST-analogue devoid of any binding affinity to SST-R but capable to bind the GHS-R1a. Cortistatin-8 can exert antagonistic effects on ghrelin actions either in vitro or in vivo in animals.
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GRF (1-29) amide (rat)
0 ImagesSynonyms: rGHRH(1-29)NH2GRF (1-29) amide (rat) is a synthetic peptide which can stimulate the growth hormone (GH) secretion.
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Ulimorelin
0 ImagesCat. No.: HY-14903CAS No.: 842131-33-3Synonyms: TZP-101Ulimorelin (TZP-101) is a ghrelin receptor (GRLN) agonist with an EC50 of 29 nM and a Ki of 16 nM. Ulimorelin is a prokinetic agent and causes vasorelaxation through competitive antagonist action at α1-adrenoceptors. Ulimorelin stimulates intestinal motility and is used for malnutrition.
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Obestatin(human)
0 ImagesObestatin(human) is a 23-amino acid amidated peptide that regulates appetite and gastrointestinal motility via its interaction with GPR39. Obestatin(human) can be used for weight loss. Obestatin(human) cannot penetrate the cell membrane.
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L-692585
0 ImagesL-692585 is a potent and nonpeptidyl growth hormone secretagogue receptor (GHS-R1a) agonist, with a Ki of 0.8 nM. L-692585 acts directly on somatotropes causing GH release.
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Emoghrelin
0 ImagesCat. No.: HY-N12348CAS No.: 928262-58-2Emoghrelin, isolated from? Heshouwu Polygonum multiflorum, stimulates growth hormone secretion via activation of the ghrelin receptor.
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PF-04628935
0 ImagesPF-04628935 (compound 10n) is a potent ghrelin receptor inverse agonist, with an IC50 of 4.6 nM. PF-04628935 exhibits oral bioavailability of 43% in rats and shows reasonable penetration into the brain. PF-04628935 can be used for stress and anxiety research.
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Acetyl-(D-Arg2)-GRF (1-29) amide (human)
0 ImagesAcetyl-(D-Arg2)-GRF (1-29) amide (human) is an antagonist of growth hormone releasing factor (GRF). Acetyl-(D-Arg2)-GRF (1-29) amide (human) inhibits the release of growth hormone (GH) and can be used for endocrine research.
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(αR,8aS)-GSK1614343
0 Images(αR,8aS)-GSK1614343 is the isomer of GSK1614343 (HY-113906). GSK1614343 is the potent antagonist of growth hormone secretagogues type 1a (GHS1a) receptors.
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GHRF, mouse TFA
0 ImagesCat. No.: HY-P3596APurity: 98.87%Synonyms: Mouse growth hormone-releasing factor TFAGHRF, mouse TFA, a mouse growth hormone-releasing factor, is a peptide containing 44 amino acids. GHRF, mouse TFA stimulates the release and synthesis of growth hormone.
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Somatostatin-25
0 ImagesCat. No.: HY-P1547CAS No.: 76461-17-1Somatostatin-25 is a endogenous neuropeptide hormone that shows inhibitory activity against secretion of growth hormone.
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L-692429
0 ImagesSynonyms: MK-0751L-692429 (MK-0751) is a benzolactam derivative and a nonpeptidyl growth hormone secretagogue (GHS) agonist. L-692429 binds to G protein-coupled receptor with a Ki of 63 nM.
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Meranzin
0 ImagesMeranzin is an orally active antidepressant and GHSR modulator. Meranzin significantly upregulates the expression levels of brain-derived neurotrophic factor and p-mTOR in the hippocampus via the ghrelin-growth hormone secretagogue receptor pathway. Meranzin regulates blood oxygen level-dependent signals in the hippocampus-thalamus-basal ganglia circuit, attenuates reward system activation, and promotes the normalization of related hormone levels. Meranzin effectively ameliorates depression-like behaviors and gastrointestinal hypomotility, and can be used in research related to depression and major depressive disorder.
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(D-Ala2)-GRF (1-29) amide (human)
0 Images(D-Ala2)-GRF (1-29) amide (human) is a superagonist of GRF, exhibiting extremely high GH-releasing activity about 50 times that of GRF (1-29) in both pigs and rats.
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Relamorelin
0 ImagesCat. No.: HY-19884CAS No.: 661472-41-9Synonyms: RM-131; BIM-28131Relamorelin (RM-131), a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for GHS-1a receptor. Relamorelin is centrally penetrant. Relamorelin increases growth hormone levels and accelerates gastric emptying. Relamorelin has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research.
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Relamorelin acetate
0 ImagesCat. No.: HY-19884ACAS No.: 1809080-14-5Synonyms: RM-131 acetate; BIM-28131 acetateRelamorelin (RM-131) acetate, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a Ki of 0.42 nM for GHS-1a receptor. Relamorelin acetate is centrally penetrant. Relamorelin acetate increases growth hormone levels and accelerates gastric emptying. Relamorelin acetate has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research.
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AZ-GHS-38
0 ImagesCat. No.: HY-176995CAS No.: 1143021-16-2AZ-GHS-38 (compound 38) is an orally active CNS-penetrant inverse agonist of growth hormone secretagogue receptor (GHS-R1a) with an IC50 of 6.7 nM. AZ-GHS-38 results in acute reduction of food intake in wild-type mice. AZ-GHS-38 can be used for anti-obesity research.
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Ghrelin receptor full agonist-2
0 ImagesCat. No.: HY-145364CAS No.: 2602452-73-1Ghrelin receptor full agonist-2 (compound 12j) is a highly potent Ghrelin receptor full agonist.
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GSK894490A
0 ImagesCat. No.: HY-115272CAS No.: 1012035-06-1GSK894490A is a non-peptide ghrelin receptor agonist.
