GHSR

GHSR Related Products (63):

By Effects:	Inhibitors (3) Agonists (31) Antagonists (12) Activators (3) Inducer (1) Control (1)

Cat. No.	Product Name	Effect	Purity

HY-14734

Anamorelin	Agonist	99.94%
Anamorelin (RC-1291) is an orally active Ghrelin receptor agonist with an EC₅₀ of 0.74 nM. Anamorelin can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin can be used in the research of anorexia and cancer cachexia.

HY-50844

Ibutamoren Mesylate	Agonist	99.86%
Ibutamoren Mesylate (MK-677) is a potent, non-peptide Growth hormone secretagogue receptor (GHSR) agonist. Ibutamoren Mesylate is an orally active growth hormone (GH) secretagogue.

HY-14734A

Anamorelin hydrochloride	Agonist	99.59%
Anamorelin (RC-1291) hydrochloride is an orally active Ghrelin receptor agonist with an EC₅₀ of 0.74 nM. Anamorelin hydrochloride can promote appetite, increase body weight, and stimulate the secretion of growth hormone and insulin-like growth factor-1. Anamorelin hydrochloride can be used in the research of anorexia and cancer cachexia.

HY-12584

PF-5190457	Inhibitor	99.26%
PF-5190457 (PF-05190457) is a potent and selective ghrelin receptor inverse agonist with a pK_i of 8.36.

HY-U00433

JMV 2959	Antagonist	99.91%
JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R_1a) antagonist with an IC₅₀ of 32 nM.

HY-12584A

(S)-PF-5190457		99.27%
(S)-PF-5190457 ((S)-PF-05190457) is the S-enantiomer of PF-5190457 (HY-12584). PF-5190457 (PF-05190457) is a potent and selective ghrelin receptor inverse agonist with a pK_i of 8.36.

HY-186165

KARI 101	Agonist
KARI 101 is a blood-brain barrier permeable acid sphingomyelinase (ASM) inhibitor. KARI 101 directly inhibits ASM activity and reduces ceramide production. KARI 101 induces Ca²⁺mobilization, activates AMPK and triggers GHSR1α internalization. KARI 101 can be used for the research of Alzheimer's disease.

HY-13964A

YIL781 hydrochloride	Antagonist	99.48%
YIL781 hydrochloride is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 hydrochloride produces a greater improvement in glucose homeostasis in rats. YIL781 hydrochloride inhibits the calcium response induced by ghrelin with pIC₅₀ values of 7.90 and 8.27, respectively.

HY-19884B

Relamorelin TFA	Agonist	99.16%
Relamorelin (RM-131) TFA, a pentapeptide ghrelin analog, is a selective ghrelin/growth hormone secretagogue receptor (GHSR) agonist with a K_i of 0.42 nM for GHS-1a receptor. Relamorelin TFA is centrally penetrant. Relamorelin TFA increases growth hormone levels and accelerates gastric emptying. Relamorelin TFA has the potential for cachexia, gastroparesis, and gastric/intestinal dysmobility disorders research.

HY-15243

Capromorelin Tartrate	Agonist	98.10%
Capromorelin Tartrate is an orally active, potent growth hormone secretagogue receptor (GHSR) agonist, with K_i of 7 nM for hGHS-R1a.

HY-P1366

des-Gln14-Ghrelin		98.21%
des-Gln14-Ghrelin is a second endogenous ligand for the growth hormone secretagogue receptor. a). des-Gln14-ghrelin potently induces increases in [Ca²⁺]i in CHO-GHSR62 cells, with an EC₅₀ of 2.4 nM.

HY-14820A

Macimorelin acetate	Agonist	99.34%
Macimorelin (EP-1572) acetate, a GH secretagogue, is an orally active GHSR agonist. Macimorelin acetate stimulates GH release. Macimorelin acetate can be used in the research of adult growth hormone deficiency (AGHD), and Cancer anorexia-cachexia syndrome (CACS).

HY-P0231

AZP-531		99.36%
AZP-531 is an analogue of unacylated ghrelin designed to improve glycaemic control and reduce weight.

HY-P10283

S1H	Antagonist	99.32%
S1H, a mimetic of hGH, is a human growth hormone receptor (hGHR) antagonist. S1H inhibits the interaction of hGH with hGHR. S1H inhibits phosphorylation of STAT5 in cells co-treated with hGH.

HY-13964

YIL781	Antagonist	99.68%
YIL781 is a potent and orally active ghrelin receptor (GHSR) antagonist. YIL781 produces a greater improvement in glucose homeostasis in rats. YIL781 inhibits the calcium response induced by ghrelin with pIC₅₀ values of 7.90 and 8.27, respectively.

HY-171962A

KARI 201 hydrochloride	Agonist	99.94%
KARI 201 hydrochloride is a selective, brain penetrant pand competitive acid sphingomyelinase (ASM) inhibitor with an IC₅₀ of 338.3?nM. KARI 201 hydrochloride is a ghrelin receptor agonist. KARI 201 hydrochloride improves neuropathological features of Alzheimer's disease.

HY-U00433A

JMV 2959 hydrochloride	Antagonist	98.09%
JMV 2959 hydrochloride is a growth hormone secretagogue receptor type 1a (GHS-R_1a) antagonist with an IC₅₀ of 32±3 nM in LLC-PK₁ cells.

HY-P1155

GRF (1-29) amide (rat)	Inducer	99.80%
GRF (1-29) amide (rat) is a synthetic peptide which can stimulate the growth hormone (GH) secretion.

HY-P1421

Obestatin(human)	Inhibitor	99.74%
Obestatin(human) is a 23-amino acid amidated peptide that regulates appetite and gastrointestinal motility via its interaction with GPR39. Obestatin(human) can be used for weight loss. Obestatin(human) cannot penetrate the cell membrane.

HY-50760

L-692585	Agonist	99.09%
L-692585 is a potent and nonpeptidyl growth hormone secretagogue receptor (GHS-R1a) agonist, with a K_i of 0.8 nM. L-692585 acts directly on somatotropes causing GH release.

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