HDAC5 Inhibitor

HDAC5 Inhibitors (32):

Cat. No.	Product Name	Effect	Purity

HY-16026

Ricolinostat	Inhibitor	99.83%
Ricolinostat (ACY-1215) is a potent and selective HDAC6 inhibitor, with an IC₅₀ of 5 nM.

HY-18361

TMP195	Inhibitor	99.19%
TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor with an IC₅₀ of 300 nM.

HY-18360

TMP269	Inhibitor	98.23%
TMP269 is a novel and selective class IIa histone deacetylase (HDAC) inhibitor with IC₅₀s of 157 nM, 97 nM, 43 nM and 23 nM for HDAC4, HDAC5, HDAC7 and HDAC9, respectively.

HY-13522

Fimepinostat	Inhibitor	99.95%
Fimepinostat (CUDC-907) potently inhibits class I PI3Ks as well as classes I and II HDAC enzymes with an IC₅₀ of 19/54/39 nM and 1.7/5.0/1.8/2.8 nM for PI3Kα/PI3Kβ/PI3Kδ and HDAC1/HDAC2/HDAC3/HDAC10 , respectively.

HY-13428

Tubacin	Inhibitor
Tubacin is a potent and selective inhibitor of HDAC6, with an IC₅₀ value of 4 nM and approximately 350-fold selectivity over HDAC1.

HY-117554

BRD9757	Inhibitor
BRD9757 is a potent, capless and selective HDAC6 inhibitor with an IC₅₀ of 30 nM.

HY-152226

MC2590	Inhibitor
MC2590 is a potent pyridine-containing histone deacetylase (HDAC) inhibitor.

HY-149208

HDAC-IN-53	Inhibitor
HDAC-IN-53 is an orally active, and selective HDAC1-3 inhibitor with IC₅₀ values of 47 nM, 125 nM, and 450 nM, respectively.

HY-15433

Quisinostat	Inhibitor	98.02%
Quisinostat (JNJ-26481585) is a potent, second-generation and orally active pan-HDAC inhibitor (HDACi), with IC₅₀ values ranging from 0.11 nM to 0.64 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11.

HY-13322

Pracinostat	Inhibitor	99.82%
Pracinostat is a potent histone deacetylase (HDAC) inhibitor, with IC₅₀s of 40-140 nM, used for cancer research.

HY-10223

CUDC-101	Inhibitor	99.19%
CUDC-101 is a potent inhibitor of HDAC, EGFR, and HER2 with IC₅₀s of 4.4, 2.4, and 15.7 nM, respectively.

HY-16699

Nexturastat A	Inhibitor	99.03%
Nexturastat A is a potent, selective HDAC6 inhibitor.

HY-14842B

Givinostat hydrochloride monohydrate	Inhibitor	≥98.0%
Givinostat hydrochloride monohydrate (ITF-2357 hydrochloride monohydrate) is a HDAC inhibitor with an IC₅₀ of 198 and 157 nM for HDAC1 and HDAC3, respectively.

HY-112719

BRD 4354	Inhibitor	99.66%
BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC₅₀s of 0.85 and 1.88 μM, respectively.

HY-16012A

Domatinostat	Inhibitor	99.43%
Domatinostat (4SC-202 free base) is a selective class I HDAC inhibitor with IC₅₀ of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively.

HY-115475

SW-100	Inhibitor	99.59%
SW-100, a selective histone deacetylase 6 (HDAC6) inhibitor with an IC₅₀ of 2.3 nM, shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes.

HY-15433A

Quisinostat dihydrochloride	Inhibitor	98.28%
Quisinostat dihydrochloride (JNJ-26481585 dihydrochloride) is an orally available, potent pan-HDAC inhibitor with IC₅₀s of 0.11 nM, 0.33 nM, 0.64 nM, 0.46 nM, and 0.37 nM for HDAC1, HDAC2, HDAC4, HDAC10 and HDAC11, respectively.

HY-119939

CHDI-390576	Inhibitor	99.42%
CHDI-390576, a potent, cell permeable and CNS penetrant class IIa histone deacetylase (HDAC) inhibitor with IC₅₀s of 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9, respectively, shows >500-fold selectivity over class I HDACs (1, 2, 3) and ~150-fold selectivity over HDAC8 and the class IIb HDAC6 isoform.

HY-126330

SS-208	Inhibitor	98.13%
SS-208 is a selective HDAC6 inhibitor, with an IC₅₀ of 12 nM.

HY-143248

KR-39038	Inhibitor	98.65%
KR-39038 is an orally active and potent GRK5 (G protein-coupled receptor kinase 5) inhibitor, with an IC₅₀ of 0.02 μM.

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