1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. BRD 4354

BRD 4354 

Cat. No.: HY-112719
Handling Instructions

BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively.

For research use only. We do not sell to patients.

BRD 4354 Chemical Structure

BRD 4354 Chemical Structure

CAS No. : 315698-07-8

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 88 In-stock
Estimated Time of Arrival: December 31
5 mg USD 80 In-stock
Estimated Time of Arrival: December 31
10 mg USD 140 Get quote
25 mg USD 280 Get quote
50 mg USD 480 Get quote
100 mg USD 810 Get quote
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of BRD 4354:

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Description

BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively.

IC50 & Target[1]

HDAC5

0.85 μM (IC50)

HDAC9

1.88 μM (IC50)

In Vitro

BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with BRD4354 having half-maximum inhibitory concentrations (IC50) of 0.85 μM and 1.88 μM, respectively. BRD 4354 also inhibits HDACs 4, 6, 7, and 8 at higher concentrations (3.88-13.8 μM) but demonstrates less of an inhibitory effect on other class I HDACs 1, 2, and 3 (IC50>40 μM) [1].

Molecular Weight

382.89

Formula

C₂₁H₂₃ClN₄O

CAS No.

315698-07-8

SMILES

OC1=C2N=CC=CC2=C(Cl)C=C1C(N3CCN(CC)CC3)C4=CC=CN=C4

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (326.46 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6117 mL 13.0586 mL 26.1172 mL
5 mM 0.5223 mL 2.6117 mL 5.2234 mL
10 mM 0.2612 mL 1.3059 mL 2.6117 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.43 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.43 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.43 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
Cell Assay
[1]

A549 adenocarcinoma cells were treated with BRD 4354 for 24 h at 10 μM, and the top 50 upregulated and top 50 down regulated genes are compared to other compound treatments involving drugs, bioactive compounds with established MoA, and novel synthetic compounds[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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BRD 4354
Cat. No.:
HY-112719
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