1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC

BRD 4354 

Cat. No.: HY-112719
Handling Instructions

BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively.

For research use only. We do not sell to patients.

BRD 4354 Chemical Structure

BRD 4354 Chemical Structure

CAS No. : 315698-07-8

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Customer Review

  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively.

IC50 & Target[1]

HDAC5

0.85 μM (IC50)

HDAC9

1.88 μM (IC50)

In Vitro

BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with BRD4354 having half-maximum inhibitory concentrations (IC50) of 0.85 μM and 1.88 μM, respectively. BRD 4354 also inhibits HDACs 4, 6, 7, and 8 at higher concentrations (3.88-13.8 μM) but demonstrates less of an inhibitory effect on other class I HDACs 1, 2, and 3 (IC50>40 μM) [1].

Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6117 mL 13.0586 mL 26.1172 mL
5 mM 0.5223 mL 2.6117 mL 5.2234 mL
10 mM 0.2612 mL 1.3059 mL 2.6117 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Cell Assay
[1]

A549 adenocarcinoma cells were treated with BRD 4354 for 24 h at 10 μM, and the top 50 upregulated and top 50 down regulated genes are compared to other compound treatments involving drugs, bioactive compounds with established MoA, and novel synthetic compounds[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

382.89

Formula

C₂₁H₂₃ClN₄O

CAS No.

315698-07-8

SMILES

OC1=C2N=CC=CC2=C(Cl)C=C1C(N3CCN(CC)CC3)C4=CC=CN=C4

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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Product Name:
BRD 4354
Cat. No.:
HY-112719
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BRD 4354

Cat. No.: HY-112719