1. Cell Cycle/DNA Damage
    Epigenetics
  2. HDAC
  3. BRD 4354 ditrifluoroacetate

BRD 4354 ditrifluoroacetate 

Cat. No.: HY-112719B Purity: 98.06%
Handling Instructions

BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively.

For research use only. We do not sell to patients.

BRD 4354 ditrifluoroacetate Chemical Structure

BRD 4354 ditrifluoroacetate Chemical Structure

Size Price Stock
10 mM * 1  mL in DMSO USD 108 Ask For Quote & Lead Time

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Description

BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9, with IC50s of 0.85 and 1.88 μM, respectively[1].

IC50 & Target[1]

HDAC5

0.85 μM (IC50)

HDAC9

1.88 μM (IC50)

Molecular Weight

610.93

Formula

C₂₅H₂₅ClF₆N₄O₅

SMILES

OC1=C2N=CC=CC2=C(Cl)C=C1C(N3CCN(CC)CC3)C4=CC=CN=C4.O=C(O)C(F)(F)F.O=C(O)C(F)(F)F

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (204.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6368 mL 8.1842 mL 16.3685 mL
5 mM 0.3274 mL 1.6368 mL 3.2737 mL
10 mM 0.1637 mL 0.8184 mL 1.6368 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.40 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.40 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.40 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

BRD 4354 ditrifluoroacetateHDACHistone deacetylasesInhibitorinhibitorinhibit

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Product Name:
BRD 4354 ditrifluoroacetate
Cat. No.:
HY-112719B
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