1228571-33-2
Chemical Structure
HDAC6-IN-82
- CAS No.: 1228571-33-2
- Formula:C22H23N3O3S
- Molecular Weight:409.50
InChIKey: KGFPPHGIBSDRGO-UHFFFAOYSA-N
SMILES: O=C(CCCCCSC1=NC(C2=CC=C(C=C2)C3=CC=CC=C3)=CC(N1)=O)NO
Biological Activity: HDAC6-IN-82 is a selective HDAC6 inhibitor with an IC50 of 4.9 nM against HDAC6. HDAC6-IN-82 inhibits HDAC1 (112 nM), HDAC2 (737 nM), HDAC3 (623 nM), HDAC8 (1140 nM), HDAC10 (91.4 nM) and HDAC11 (219 nM). HDAC6-IN-82 reduces cancer cell viability, induces cell cycle arrest, triggers apoptosis, and increases the acetylation levels of H3K9 and α-tubulin. HDAC6-IN-82 can be used in cancer-related research such as leukemia[1].
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HDAC6-IN-82 | HDAC6-IN-82 is a selective HDAC6 inhibitor with an IC50 of 4.9 nM against HDAC6. HDAC6-IN-82 inhibits HDAC1 (112 nM), HDAC2 (737 nM), HDAC3 (623 nM), HDAC8 (1140 nM), HDAC10 (91.4 nM) and HDAC11 (219 nM). HDAC6-IN-82 reduces cancer cell viability, induces cell cycle arrest, triggers apoptosis, and increases the acetylation levels of H3K9 and α-tubulin. HDAC6-IN-82 can be used in cancer-related research such as leukemia. | |||||||||||||||||||||
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Keywords
