HSV-2
HSV-2 uses envelope glycoprotein D (gD) to recognize nectin-1 and initiate host-cell entry, making receptor binding a core biological function for infection models[1]. Mechanistically, HSV-2 alters mucosal innate immunity by blocking type I interferon production, which helps the virus cross genital mucosal defenses[2]. In disease research, genital HSV-2 shedding explains transmission risk because symptomatic infection sheds more frequently than asymptomatic infection[3]. Compared with HSV-1, HSV-2 keeps a conserved nectin-1 recognition mode but generates greater genetic diversity during controlled cell-culture evolution[1][4]. For experimental applications, soluble nectin-1 can block vaginal HSV-1 and HSV-2 infection, while valacyclovir reduces genital HSV-2 transmission in discordant couples[5][6].
References:
- [1]. Lu G, et al. Crystal structure of herpes simplex virus 2 gD bound to nectin-1 reveals a conserved mode of receptor recognition. J Virol. 2014 Dec;88(23):13678-88. [Content Brief]
- [2]. Peng T, et al. Evasion of the mucosal innate immune system by herpes simplex virus type 2. J Virol. 2009 Dec;83(23):12559-68. [Content Brief]
- [3]. Tronstein E, et al. Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection. JAMA. 2011 Apr 13;305(14):1441-9. [Content Brief]
- [4]. López-Muñoz AD, et al. Herpes simplex virus 2 (HSV-2) evolves faster in cell culture than HSV-1 by generating greater genetic diversity. PLoS Pathog. 2021 Aug 26;17(8):e1009541. [Content Brief]
- [5]. Linehan MM, et al. In vivo role of nectin-1 in entry of herpes simplex virus type 1 (HSV-1) and HSV-2 through the vaginal mucosa. J Virol. 2004 Mar;78(5):2530-6. [Content Brief]
- [6]. Corey L, et al. Once-daily valacyclovir to reduce the risk of transmission of genital herpes. N Engl J Med. 2004 Jan 1;350(1):11-20. [Content Brief]
All Product Categories
-
HSV-2 Related Products (43)
Related Products (43)
-
Lauryl sulfate
0 ImagesLauryl sulfate (Dodecyl hydrogen sulphate) is an anionic chaotropic surfactant. Lauryl sulfate dissolves viral envelopes, denatures viral proteins, inhibits viral infectivity and HIV-1 syncytium formation. Lauryl sulfate potently inhibits the infectivity of HSV-1 strain F (ED50 = 17.9 μM) and HSV-2 strain 333 (ED50 = 32.7 μM). Lauryl sulfate induces environmental toxicity, disrupting environmental balance and physiological processes of organisms. As a contaminant, Lauryl sulfate is toxic to aquatic and terrestrial organisms. Lauryl sulfate can be used in studies related to sexually transmitted infections.
-
SCH-43478
0 ImagesCat. No.: HY-121763CAS No.: 112446-99-8
