HSV-2
HSV-2 uses envelope glycoprotein D (gD) to recognize nectin-1 and initiate host-cell entry, making receptor binding a core biological function for infection models[1]. Mechanistically, HSV-2 alters mucosal innate immunity by blocking type I interferon production, which helps the virus cross genital mucosal defenses[2]. In disease research, genital HSV-2 shedding explains transmission risk because symptomatic infection sheds more frequently than asymptomatic infection[3]. Compared with HSV-1, HSV-2 keeps a conserved nectin-1 recognition mode but generates greater genetic diversity during controlled cell-culture evolution[1][4]. For experimental applications, soluble nectin-1 can block vaginal HSV-1 and HSV-2 infection, while valacyclovir reduces genital HSV-2 transmission in discordant couples[5][6].
References:
- [1]. Lu G, et al. Crystal structure of herpes simplex virus 2 gD bound to nectin-1 reveals a conserved mode of receptor recognition. J Virol. 2014 Dec;88(23):13678-88. [Content Brief]
- [2]. Peng T, et al. Evasion of the mucosal innate immune system by herpes simplex virus type 2. J Virol. 2009 Dec;83(23):12559-68. [Content Brief]
- [3]. Tronstein E, et al. Genital shedding of herpes simplex virus among symptomatic and asymptomatic persons with HSV-2 infection. JAMA. 2011 Apr 13;305(14):1441-9. [Content Brief]
- [4]. López-Muñoz AD, et al. Herpes simplex virus 2 (HSV-2) evolves faster in cell culture than HSV-1 by generating greater genetic diversity. PLoS Pathog. 2021 Aug 26;17(8):e1009541. [Content Brief]
- [5]. Linehan MM, et al. In vivo role of nectin-1 in entry of herpes simplex virus type 1 (HSV-1) and HSV-2 through the vaginal mucosa. J Virol. 2004 Mar;78(5):2530-6. [Content Brief]
- [6]. Corey L, et al. Once-daily valacyclovir to reduce the risk of transmission of genital herpes. N Engl J Med. 2004 Jan 1;350(1):11-20. [Content Brief]
All Product Categories
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HSV-2 Related Products (43)
Related Products (43)
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FIT-039
0 ImagesFIT-039 is a selective, ATP-competitive and orally active CDK9 inhibitor with an IC50 of 5.8 μM for CKD9/cyclin T1. FIT-039 does not inhibit other CDKs and other kinases. FIT-039 inhibits replication of HSV-1 (IC50 of 0.69 μM), HSV-2, human adenovirus, and human CMV. FIT-039 is a promising antiviral agent for inhibiting drug-resistant HSVs and other DNA viruses.
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Casuarinin
0 ImagesCat. No.: HY-N12717CAS No.: 79786-01-9Casuarinin is an orally active antiproliferative, anti-inflammatory, antifungal, virucidal and gastroprotective agent. Casuarinin upregulates the expression of p21/WAF1, Fas/APO‑1, mFasL, sFasL and HSP‑70, arrests cell cycle, induces apoptosis and inhibits cancer cell proliferation. Casuarinin inhibits TNF‑α-induced phosphorylation of MAPK and activation of NF‑κB, downregulates the expression of iNOS, NF‑κB, COX‑2 and ICAM‑1, and reduces the production of proinflammatory mediators. Casuarinin attenuates ethanol-induced activation of caspase‑3 and elevation of TNF‑α, inhibits the growth of Candida albicans, and inhibits HSV‑2. Casuarinin can be used in research related to mammary adenocarcinoma, inflammatory skin diseases, gastric ulcers, candidiasis and herpes simplex virus infections.
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Pritelivir mesylate
0 ImagesSynonyms: AIC316 mesylate; BAY 57-1293 mesylatePritelivir mesylate (BAY 57-1293 mesylate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2.
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Pritelivir mesylate hydrate
0 ImagesSynonyms: AIC316 mesylate hydrate; BAY 57-1293 mesylate hydratePritelivir mesylate hydrate (BAY 57-1293 mesylate hydrate), an inhibitor of the viral helicase-primase complex, exhibits antiviral activity in vitro and in animal models of herpes simplex virus (HSV) infection. Pritelivir mesylate hydrate is active against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2) with the IC50 of 0.02 μM against HSV1-2.
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Fiacitabine
0 ImagesSynonyms: NSC 382097; FIAC; FOACFiacitabine (NSC 382097; FIAC; FOAC) is a potent and highly selective anti-herpesvirus agent. Fiacitabine acts as an inhibitor of HSV DNA polymerase, with a Ki of 0.26 μM for HSV-1 and 0.42 μM for HSV-2, respectively. Fiacitabine can be efficiently phosphorylated by thymidine kinase encoded by the virus itself to generate FIACTP, an active triphosphate metabolite. Fiacitabine is applicable to research related to herpesvirus infections.
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Tromantadine
0 ImagesCat. No.: HY-U00124CAS No.: 53783-83-8
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Penciclovir sodium
0 ImagesCat. No.: HY-107739CAS No.: 97845-62-0Synonyms: VSA 671 sodium; BRL 39123A; BRL 39123D
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Ganciclovir hydrate
0 ImagesCat. No.: HY-13637BCAS No.: 1359968-33-4Synonyms: BW-759 hydrate; 2'-Nor-2'-deoxyguanosine hydrateGanciclovir (BW 759) hydrate, a nucleoside analogue, is an orally active antiviral agent with activity against CMV. Ganciclovir hydrate also has activity in vitro against members of the herpes group and some other DNA viruses. Ganciclovir hydrate inhibits the in vitro replication of human herpes viruses (HSV 1 and 2, CMV) and adenovirus serotypes 1, 2, 4, 6, 8, 10, 19, 22 and 28. Ganciclovir hydrate has an IC50 of 5.2 μM for feline herpesvirus type-1 (FHV-1) and can diffuse into the brain.
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2-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol
0 ImagesCat. No.: HY-N13837CAS No.: 2266586-31-42-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol (Compound 1) is a 9,10-dihydrophenanthrene derivative. 2-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol can be isolated from Juncus compressus. 2-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol exhibits anticancer activity against cervical and ovarian cancers. 2-Methoxy-1,6-dimethyl-5-vinyl-9,10-dihydrophenanthren-7-ol can be used for HSV-2 virus research.
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North-methanocarbathymidine
0 ImagesCat. No.: HY-104083CAS No.: 156126-12-4Synonyms: N-MCTNorth-methanocarbathymidine (N-MCT) is a potent antiviral agent. North-methanocarbathymidine inhibits DNA synthesis. North-methanocarbathymidine demonstrates potent antiviral activity against HSV-1, HSV-2 and KSHV. North-methanocarbathymidine exhibits anticancer activity against colon adenocarcinoma expressing HSV-tk.
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1,2,4,6-Tetra-O-galloyl-β-D-glucose
0 ImagesCat. No.: HY-N15572CAS No.: 84297-49-41,2,4,6-Tetra-O-galloyl-β-D-glucose is an acetylcholinesterase inhibitor with an IC50 of 1.5 μM against human targets. 1,2,4,6-Tetra-O-galloyl-β-D-glucose inhibits the aggregation of amyloid-β. 1,2,4,6-Tetra-O-galloyl-β-D-glucose exhibits anti-herpesvirus activity against both HSV-1 and HSV-2 in vitro. 1,2,4,6-Tetra-O-galloyl-β-D-glucose possesses superoxide dismutase-like antioxidant activity, and also inhibits tyrosinase and hyaluronidase. 1,2,4,6-Tetra-O-galloyl-β-D-glucose can be used in studies related to Alzheimer's disease, herpesvirus infection and antioxidation.
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WAY-150138
0 ImagesCat. No.: HY-123211CAS No.: 273388-09-3WAY-150138 inhibits replication of herpes simplex virus type 1 (HSV-1) that acts by preventing the incorporation of DNA-packaging proteins into capsids as they are assembled
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G2-Peptide
0 ImagesCat. No.: HY-P3795CAS No.: 361443-81-4G2-Peptide is a 3-O-sulfated heparan sulfate (3-OS HS) binder and antiviral agent. G2-Peptide blocks herpesvirus attachment, entry, cell-to-cell spread and syncytium formation, and reduces viral protein translocation. G2-Peptide exhibits antiviral activity against both HSV-1 and HSV-2. G2-Peptide inhibits neural activity and impairs synapse assembly. G2-Peptide can be used in the research of genital herpes, ocular herpes infection and keratitis.
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Rhusflavanone
0 ImagesCat. No.: HY-N19905CAS No.: 53060-72-3Rhusflavanone is a biflavonoid found in the stamens of Mesua ferrea. Rhusflavanone IC50 values against elastase and tyrosinase are 10.6 and 14.3 μg/mL, respectively. Rhusflavanone inhibits the replication of influenza B virus, SARS-CoV-2, Measles virus and HSV-2, and suppresses the secretion of Salmonella T3SS effector proteins. Rhusflavanone inhibits the production of pro-inflammatory mediators and exerts cytotoxic effects on cancer cells. Rhusflavanone can be used in research related to colon cancer, breast cancer, cervical cancer, COVID-19, influenza B, measles, HSV-2 infection and Salmonella infection.
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5-(4-Carboxyphenyl)-10,15,20-triphenylporphyrin
0 ImagesCat. No.: HY-W035144CAS No.: 95051-10-85-(4-Carboxyphenyl)-10,15,20-triphenylporphyrin is a porphyrin compound. 5-(4-Carboxyphenyl)-10,15,20-triphenylporphyrin exhibits virucidal effects of 85% and 60% against HSV-1 and HSV-2, respectively. 5-(4-Carboxyphenyl)-10,15,20-triphenylporphyrin has a maximum noncytotoxic studied concentration of 5 μg/mL on Vero cells. 5-(4-Carboxyphenyl)-10,15,20-triphenylporphyrin can be used for the synthesis of compounds with stronger antiviral activity.
