PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Aminooxy-PEG8-acid
0 ImagesCat. No.: HY-140395CAS No.: 2055269-60-6
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THP-C4-PEG4
0 ImagesCat. No.: HY-138465CAS No.: 3026715-55-6
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PEG7-O-MS
0 ImagesCat. No.: HY-140389CAS No.: 1217601-12-1
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m-PEG4-amino-Mal
0 ImagesCat. No.: HY-130181CAS No.: 1263044-81-0
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N-(Biotin-PEG4)-N-bis(PEG4-Boc)
0 ImagesCat. No.: HY-141288CAS No.: 2112730-79-5
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Boc-PEG2-sulfonic acid
0 ImagesCat. No.: HY-140173CAS No.: 1817735-40-2
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m-PEG24-SH
0 ImagesCat. No.: HY-133275CAS No.: 3024858-88-3
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3-(Dimethoxymethyl)-1-oxa-8-azaspiro[4.5]decane
![3-(Dimethoxymethyl)-1-oxa-8-azaspiro[4.5]decane](https://file.medchemexpress.com/product_pic/hy-w889109.gif "Click to View 3-(Dimethoxymethyl)-1-oxa-8-azaspiro[4.5]decane Product Detail")
0 ImagesCat. No.: HY-W889109CAS No.: 3026011-77-5
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m-PEG8-Mal
0 ImagesCat. No.: HY-140982CAS No.: 1334169-90-2
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Azido-PEG1-C1-Boc
0 ImagesCat. No.: HY-140792CAS No.: 1820717-35-8Azido-PEG1-C1-Boc is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG1-C1-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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1,4-Dimethylpiperidine
0 ImagesCat. No.: HY-W655179CAS No.: 695-15-81,4-Dimethylpiperidine is a PROTAC linker.
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Carboxy-PEG4-phosphonic acid ethyl ester
0 ImagesCat. No.: HY-141303CAS No.: 1964503-39-6
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Methyl acetate-PEG1
0 ImagesCat. No.: HY-W096155CAS No.: 58349-37-4
