PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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Azido-PEG11-CH2COOH
0 ImagesCat. No.: HY-138415CAS No.: 2567584-97-6Azido-PEG11-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG11-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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THP-PEG13-Boc
0 ImagesCat. No.: HY-138478CAS No.: 2923530-16-7
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Bis-propargyl-PEG12
0 ImagesCat. No.: HY-140040CAS No.: 1351373-50-6
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Trityl-PEG8-azide
0 ImagesCat. No.: HY-140860CAS No.: 1818294-30-2Trityl-PEG8-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Trityl-PEG8-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Acid-PEG6-mono-methyl ester
0 ImagesCat. No.: HY-140486CAS No.: 1807512-38-4
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endo-BCN-PEG4-Boc
0 ImagesCat. No.: HY-140074CAS No.: 1807501-83-2
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N-(m-PEG4)-N'-(Biotin-PEG2-amido-PEG4)-Cy5
0 ImagesCat. No.: HY-141069CAS No.: 2107273-78-7
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Azido-PEG2-C6-OH
0 ImagesCat. No.: HY-138471Azido-PEG2-C6-OH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG2-C6-OH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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m-PEG4-phosphonic acid ethyl ester
0 ImagesCat. No.: HY-141311CAS No.: 1872433-73-2
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Fmoc-PEG5-NHBoc
0 ImagesCat. No.: HY-138330CAS No.: 2957835-14-0
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Chloro-PEG5-chloride
0 ImagesCat. No.: HY-W096131CAS No.: 5197-65-9
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Benzyl-PEG6-azide
0 ImagesCat. No.: HY-W096070CAS No.: 86770-73-2Benzyl-PEG6-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Benzyl-PEG6-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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N-Boc-N-bis(PEG3-acid)
0 ImagesCat. No.: HY-140539CAS No.: 2055023-35-1
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Azido-PEG20-Boc
0 ImagesCat. No.: HY-138457Azido-PEG20-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG20-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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SPDP-PEG12-NHS ester
0 ImagesCat. No.: HY-141356CAS No.: 2601437-72-1
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Hydroxy-PEG3-acrylate
0 ImagesCat. No.: HY-141244CAS No.: 16695-45-7
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N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(azide-PEG4)-Cy5
0 ImagesCat. No.: HY-141068CAS No.: 2107273-58-3N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(m-PEG4)-N'-(m-PEG4)-O-(m-PEG4)-O'-(azide-PEG4)-Cy5 is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
