PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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N-Ethylheptanamide
0 ImagesCat. No.: HY-163989CAS No.: 54007-34-0N-Ethylheptanamide is a PROTAC linker. N-Ethylheptanamide can be used in synthesis PROTAC FGFR2 degrader 1 (HY-163985).
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DBCO-NHCO-PEG5-NHS ester
0 ImagesCat. No.: HY-140275CAS No.: 1378531-80-6
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Bromoacetamido-C2-PEG2-NH-Boc
0 ImagesCat. No.: HY-141199CAS No.: 182244-33-3
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HO-PEG24-CH2COOH
0 ImagesCat. No.: HY-133305CAS No.: 2933173-82-9
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Bis-PEG2-PFP ester
0 ImagesBis-PEG2-PFP ester is also a non-cleavable 2 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Bis-PEG2-PFP ester is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs.
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m-PEG8-ethoxycarbonyl-propanoic acid
0 ImagesCat. No.: HY-140503CAS No.: 2353409-75-1
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N3-PEG3400-NH2
0 ImagesCat. No.: HY-W1048572DSynonyms: Azide-PEG3400-AmineN3-PEG3400-NH2 (Azide-PEG3400-Amine) is a hetero-bifunctional PEG product with an azide and an amine group at the PEG terminus. N3-PEG3400-NH2 is an important cross-linker with PEG chains. The azide can be used for molecular conjugation through chemical reactions, and the amine can react with carboxylic acid or NHS ester.
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Chloroacetamido-C4-NHBoc
0 ImagesCat. No.: HY-W096152CAS No.: 133264-58-1
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Azido-PEG11-CH2COOH
0 ImagesCat. No.: HY-138415CAS No.: 2567584-97-6Azido-PEG11-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG11-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
