2. PROTAC
  3. PROTAC Linkers
  4. m-PEG8-O-alkyne

m-PEG8-O-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG8-O-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

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m-PEG8-O-alkyne Chemical Structure

m-PEG8-O-alkyne Chemical Structure

CAS No. : 880081-81-2

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25 mg USD 95 In-stock
50 mg USD 140 In-stock
100 mg USD 210 In-stock
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Based on 1 publication(s) in Google Scholar

m-PEG8-O-alkyne Related Antibodies

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Description

m-PEG8-O-alkyne is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. m-PEG8-O-alkyne is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC50 & Target

PEGs

 

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

m-PEG8-O-alkyne Related Antibodies
Molecular Weight

422.51

Formula

C20H38O9
CAS No.
Appearance

Liquid

Color

Colorless to light yellow

SMILES

COCCOCCOCCOCCOCCOCCOCCOCCOCC#C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (236.68 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3668 mL 11.8340 mL 23.6681 mL
5 mM 0.4734 mL 2.3668 mL 4.7336 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3668 mL 11.8340 mL 23.6681 mL 59.1702 mL
5 mM 0.4734 mL 2.3668 mL 4.7336 mL 11.8340 mL
10 mM 0.2367 mL 1.1834 mL 2.3668 mL 5.9170 mL
15 mM 0.1578 mL 0.7889 mL 1.5779 mL 3.9447 mL
20 mM 0.1183 mL 0.5917 mL 1.1834 mL 2.9585 mL
25 mM 0.0947 mL 0.4734 mL 0.9467 mL 2.3668 mL
30 mM 0.0789 mL 0.3945 mL 0.7889 mL 1.9723 mL
40 mM 0.0592 mL 0.2959 mL 0.5917 mL 1.4793 mL
50 mM 0.0473 mL 0.2367 mL 0.4734 mL 1.1834 mL
60 mM 0.0394 mL 0.1972 mL 0.3945 mL 0.9862 mL
80 mM 0.0296 mL 0.1479 mL 0.2959 mL 0.7396 mL
100 mM 0.0237 mL 0.1183 mL 0.2367 mL 0.5917 mL
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m-PEG8-O-alkyne Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

m-PEG8-O-alkyne880081-81-2PROTAC LinkersInhibitorinhibitorinhibit

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