PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
-
PROTAC Linkers Related Products (4102)
Related Products (4102)
-
PROTAC Linkers Isoform Comparison
-
Aminooxy-PEG3-C2-Boc
0 ImagesCat. No.: HY-140401CAS No.: 1835759-72-2
-
Bromo-PEG2-phosphonic acid
0 ImagesCat. No.: HY-141297CAS No.: 1446282-44-5
-
THP-PEG6-C2-Boc
0 ImagesCat. No.: HY-138349CAS No.: 2923530-10-1
-
Pyrene-amido-PEG4-CH2CH2COOH
0 ImagesCat. No.: HY-130397CAS No.: 1817735-34-4
-
m-PEG3-Sulfone-PEG3-azide
0 ImagesCat. No.: HY-140606CAS No.: 1895922-76-5m-PEG3-Sulfone-PEG3-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. m-PEG3-Sulfone-PEG3-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
m-PEG20-alcohol
0 ImagesCat. No.: HY-W096138CAS No.: 1059605-06-9
-
m-PEG4-Hydrazide
0 ImagesCat. No.: HY-141402CAS No.: 1449390-68-4
-
Biotin-PEG4-hydrazide TFA
0 ImagesCat. No.: HY-140932A
-
Azido-PEG36-Boc
0 ImagesCat. No.: HY-140785Azido-PEG36-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG36-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
Bis-PEG17-NHS ester
0 ImagesCat. No.: HY-130826CAS No.: 2221948-93-0Bis-PEG17-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG17-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
-
Azido-PEG4-amido-PEG4-Boc
0 ImagesCat. No.: HY-140786Azido-PEG4-amido-PEG4-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-amido-PEG4-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
Cbz-NH-PEG8-C2-acid
0 ImagesCat. No.: HY-130192CAS No.: 1334177-87-5
-
Bis-propargyl-PEG2
0 ImagesCat. No.: HY-133191CAS No.: 126422-57-9Bis-propargyl-PEG2 is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Bis-propargyl-PEG2 is used for the synthesis of demethylvancomycin dimers. Bis-propargyl-PEG2 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
