PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
-
PROTAC Linkers Related Products (4102)
Related Products (4102)
-
PROTAC Linkers Isoform Comparison
-
S-acetyl-PEG2-Boc
0 ImagesCat. No.: HY-141345CAS No.: 1820641-93-7
-
Biotin-PEG12-acid
0 ImagesCat. No.: HY-140493CAS No.: 1621423-14-0
-
Benzyl-PEG8-azide
0 ImagesCat. No.: HY-132010Benzyl-PEG8-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Benzyl-PEG8-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
m-PEG4-C6-phosphonic acid ethyl ester
0 ImagesCat. No.: HY-141314CAS No.: 2028281-89-0
-
TCO-C3-PEG3-C3-amine
0 ImagesCat. No.: HY-141182CAS No.: 2028288-77-7
-
NH2-PEG3 hydrochloride
0 ImagesCat. No.: HY-W096143CAS No.: 92505-84-5
-
N-Boc-N-bis-PEG5
0 ImagesCat. No.: HY-140553CAS No.: 2093154-02-8
-
Propargyl-PEG12-bromide
0 ImagesCat. No.: HY-135823CAS No.: 2410937-34-5
-
Boc-NH-PEG4-azide
0 ImagesCat. No.: HY-140836CAS No.: 940951-99-5Boc-NH-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Boc-NH-PEG4-azide is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
Amino-PEG36-alcohol
0 ImagesCat. No.: HY-140207CAS No.: 2718868-96-1
-
Boc-NH-PEG15-C1-acid
0 ImagesCat. No.: HY-138402CAS No.: 2688072-53-7
-
N-(m-PEG4)-N'-(PEG3-Mal)-Cy5
0 ImagesCat. No.: HY-141076CAS No.: 2839527-02-3
-
Propargyl-PEG4-CH2CH2-Boc
0 ImagesCat. No.: HY-130293CAS No.: 1245823-50-0Propargyl-PEG4-CH2CH2-Boc is a non-cleavable ADC linker that can be used to synthesize ADC inhibitors of Galectin-3. Propargyl-PEG4-CH2CH2-Boc is a PEG- and Alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs. Propargyl-PEG4-CH2CH2-Boc is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
-
N-(Boc-PEG3)-N-bis(PEG3-azide)
0 ImagesCat. No.: HY-140871CAS No.: 2182602-15-7N-(Boc-PEG3)-N-bis(PEG3-azide) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. N-(Boc-PEG3)-N-bis(PEG3-azide) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
-
Bromo-PEG2-MS
0 ImagesCat. No.: HY-132042CAS No.: 1935075-34-5
