PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
PROTAC Linkers Isoform Specific Products
All Product Categories
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PROTAC Linkers Related Products (4102)
Related Products (4102)
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PROTAC Linkers Isoform Comparison
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TCO-PEG5-NHS ester
0 ImagesCat. No.: HY-171559CAS No.: 2714310-77-5
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Azido-PEG4-formylhydrazine-Boc
0 ImagesCat. No.: HY-138388Azido-PEG4-formylhydrazine-Boc is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Azido-PEG4-formylhydrazine-Boc is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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Methylamino-PEG1-acid
0 ImagesCat. No.: HY-140000CAS No.: 1367918-21-5
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Boc-NH-PEG1-C5-OH
0 ImagesCat. No.: HY-134737CAS No.: 2711732-75-9
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MS-PEG3-dodecyl
0 ImagesCat. No.: HY-132063CAS No.: 2148295-99-0
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Aminooxy-PEG8-methane
0 ImagesCat. No.: HY-140400CAS No.: 2055024-52-5
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Cbz-NH-PEG6-C2-acid
0 ImagesCat. No.: HY-130443CAS No.: 1334177-80-8
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Trt-PEG4-C2-acid hydrate
0 ImagesCat. No.: HY-W096111ACAS No.: 1189873-11-7
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Mal-amido-PEG24-TFP ester
0 ImagesCat. No.: HY-140981CAS No.: 2384191-62-0
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Tetrazine-Ph-PEG5-Ph-tetrazine
0 ImagesCat. No.: HY-133463Tetrazine-Ph-PEG5-Ph-tetrazine is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs. Tetrazine-Ph-PEG5-Ph-tetrazine is a click chemistry reagent, it contains a Tetrazine group that can undergo an inverse electron demand Diels-Alder reaction (iEDDA) with molecules containing TCO groups.
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Benzyl-PEG4-THP
0 ImagesCat. No.: HY-132008CAS No.: 1027926-86-8
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m-PEG6-MS
0 ImagesCat. No.: HY-140364CAS No.: 130955-39-4
