Br-C10-methyl ester

Cat. No.: HY-130641 Purity: 97.87%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Br-C10-methyl ester is a PROTAC linker, which refers to the alkyl/ether composition. Br-C10-methyl ester is used in the synthesis of a series of PROTACs (MS432). PROTACs contain two different ligands connected by a linker; one is the VHL ligand portion and the other is for the target protein.

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Br-C10-methyl ester Chemical Structure

CAS No. : 6287-90-7

Size	Price	Stock	Quantity
100 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Based on 1 publication(s) in Google Scholar

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PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

Alkyl/ether

Molecular Weight

279.21

Formula

C₁₂H₂₃BrO₂

CAS No.

6287-90-7

Appearance

<12.5°C Solid,>12.5°C Liquid

Color

Colorless to light yellow

SMILES

O=C(OC)CCCCCCCCCCBr

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (358.15 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5815 mL	17.9077 mL	35.8153 mL
5 mM	0.7163 mL	3.5815 mL	7.1631 mL
10 mM	0.3582 mL	1.7908 mL	3.5815 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 97.87%

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Data Sheet (265 KB) SDS (393 KB)

COA (239 KB) HNMR (96 KB) GC (191 KB)

Handling Instructions (2659 KB)

References

[1]. Wei J, et al. Discovery of a First-in-Class Mitogen-Activated Protein Kinase Kinase 1/2 Degrader.J Med Chem. 2019 Dec 12;62(23):10897-10911. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5815 mL	17.9077 mL	35.8153 mL	89.5383 mL
	5 mM	0.7163 mL	3.5815 mL	7.1631 mL	17.9077 mL
	10 mM	0.3582 mL	1.7908 mL	3.5815 mL	8.9538 mL
	15 mM	0.2388 mL	1.1938 mL	2.3877 mL	5.9692 mL
	20 mM	0.1791 mL	0.8954 mL	1.7908 mL	4.4769 mL
	25 mM	0.1433 mL	0.7163 mL	1.4326 mL	3.5815 mL
	30 mM	0.1194 mL	0.5969 mL	1.1938 mL	2.9846 mL
	40 mM	0.0895 mL	0.4477 mL	0.8954 mL	2.2385 mL
	50 mM	0.0716 mL	0.3582 mL	0.7163 mL	1.7908 mL
	60 mM	0.0597 mL	0.2985 mL	0.5969 mL	1.4923 mL
	80 mM	0.0448 mL	0.2238 mL	0.4477 mL	1.1192 mL
	100 mM	0.0358 mL	0.1791 mL	0.3582 mL	0.8954 mL