Coccidia
Coccidia comprise protozoan parasites including Toxoplasma gondii, Neospora caninum, Eimeria spp., and Cystoisospora spp., and their life cycle switches between asexual and sexual stages[1]. Mechanistically, Eimeria invasion depends on coccidian organelles and host-cell interaction during intestinal infection[2][3]. In poultry models, Eimeria invades the intestinal tract and causes coccidiosis, with disease severity and lesions varying by parasite species[4][3]. Compared with T. gondii, which infects warm-blooded animals asexually but restricts sexual development to felines, Eimeria usually completes its whole life cycle in one host species[5]. For experimental applications, monolayer cultures, organoids, axenic systems, and host cell-free Cystoisospora suis models support research on parasite development, invasion, host-parasite interaction, and anticoccidial drug targets[1][6].
Verweise:
- [1]. Feix AS, et al. In vitro cultivation methods for coccidian parasite research. Int J Parasitol. 2023 Aug;53(9):477-489. [Content Brief]
- [2]. Burrell A, et al. Life cycle stages, specific organelles and invasion mechanisms of Eimeria species. Parasitology. 2020 Mar;147(3):263-278. [Content Brief]
- [3]. López-Osorio S, et al. Overview of Poultry Eimeria Life Cycle and Host-Parasite Interactions. Front Vet Sci. 2020 Jul 3;7:384. [Content Brief]
- [4]. Mesa-Pineda C, et al. Chicken Coccidiosis: From the Parasite Lifecycle to Control of the Disease. Front Vet Sci. 2021 Dec 21;8:787653. [Content Brief]
- [5]. Martorelli Di Genova B, et al. Comparisons of the Sexual Cycles for the Coccidian Parasites Eimeria and Toxoplasma. Front Cell Infect Microbiol. 2020 Dec 14;10:604897. [Content Brief]
- [6]. Feix AS, et al. Progression of asexual to sexual stages of Cystoisospora suis in a host cell-free environment as a model for Coccidia. Parasitology. 2021 Oct;148(12):1475-1481. [Content Brief]
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Coccidia Verwandte Produkte (28)
Verwandte Produkte (28)
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Toltrazuril sulfoxide
0 ImagesToltrazuril sulfoxide is a short-lived intermediary metabolite of Toltrazuril (HY-B0175), and then can be metabolized to the reactive toltrazuril sulfone (TZR-SO2) in vivo. Toltrazuril is an antiprotozoal agent that acts upon Coccidia parasites.
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Dinitolmide
0 ImagesDinitolmide (Zoalene) is an orally active anticoccidial agent used as a fodder additive. Dinitolmide has a wide anticoccidial spectrum with no effect on host immunity. Dinitolmide mainly acts on the first generation merozoite stage of coccidia and also has an inhibitory effect on the sporulation process of oocysts. Dinitolmide has anti-Toxoplasma gondii effect in vitro with an EC50 of 3.625 μg/mL. Dinitolmide can be used to inhibits infections caused by Eimeria tenella.
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Sulfaquinoxaline-d4
0 ImagesArt. -Nr.: HY-B1282SCAS. Nr.: 1329652-02-9Sulfaquinoxaline-d4 is the deuterium labeled Sulfaquinoxaline. Sulfaquinoxaline is an antimicrobial for veterinary use, with activity against a broad spectrum of Gram-negative and Gram-positive bacteria. Sulfaquinoxaline is used to prevent coccidiosis and bacterial infections.
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Clazuril
0 ImagesArt. -Nr.: HY-101000CAS. Nr.: 101831-36-1Synonyms: R62690Clazuril (R62690) has a coccidiocidal effect on the asexual and sexual developmental stages of both Eimeria species, resulting in a complete interruption of the life cycle.
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Nequinate
0 ImagesArt. -Nr.: HY-116433CAS. Nr.: 13997-19-8Nequinate, a quinoline compound, is an anticoccidial agent against cecal coccidiosis (Eimeria tenella) infections. Nequinate inhibits xanthine oxidoreductase (XOD) activity.
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Anticoccidial agent-1
0 ImagesArt. -Nr.: HY-183528CAS. Nr.: 762172-81-6Anticoccidial agent-1 is an imidazopyridine anticoccidial agent with an IC50 of 0.044. Anticoccidial agent-1 can be used for the research of coccidiosis.
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Sulfadimethoxine 1000 µg/mL in methanol
0 ImagesSulfadimethoxine (Sulphadimethoxine) 1000 µg/mL in methanol is an orally active sulfonamide antibiotic. Sulfadimethoxine 1000 µg/mL in methanol reduces Eimeria-related mortality, weight loss, and lesions. Sulfadimethoxine 1000 µg/mL in methanol can be used for the research of avian coccidiosis.
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