Potassium Channel
KcsA
Potassium channels are the most widely distributed type of ion channel and are found in virtually all living organisms. They form potassium-selective pores that span cell membranes. Potassium channels are found in most cell types and control a wide variety of cell functions. Potassium channels function to conduct potassium ions down their electrochemical gradient, doing so both rapidly and selectively. Biologically, these channels act to set or reset the resting potential in many cells. In excitable cells, such asneurons, the delayed counterflow of potassium ions shapes the action potential. By contributing to the regulation of the action potential duration in cardiac muscle, malfunction of potassium channels may cause life-threatening arrhythmias. Potassium channels may also be involved in maintaining vascular tone.
All Product Categories
-
Potassium Channel Inhibitors
(686)
View all products
-
Potassium Channel Agonists
(31)
View all products
-
Potassium Channel Antagonists
(39)
View all products
-
Potassium Channel Activators
(243)
View all products
-
Potassium Channel Modulators
(44)
View all products
-
Potassium Channel Chemical
(1)
View all products
-
Potassium Channel Controls
(11)
View all products
-
Potassium Channel Related Products (1149)
Related Products (1149)
-
Antibodies (6)
-
Related Compound Screening Libraries (1)
-
Ifenprodil tartrate (Standard)
0 ImagesSynonyms: NP-120 tartrate (Standard); RC-61-91 tartrate (Standard)Ifenprodil (tartrate) (Standard) is the analytical standard of Ifenprodil (tartrate). This product is intended for research and analytical applications. Ifenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM). Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator.
-
Lig4-4
0 ImagesCat. No.: HY-W269032CAS No.: 3598-68-3Lig4-4 is an orally active and selective TREK-1 inhibitor, with an IC50 of 2.06 μM in rats. Lig4-4 improves neuronal viability, reduces cell apoptosis by upregulating cleaved-caspase-3 and downregulating Bcl-2, and decreases infarct volume. Lig4-4 exerts a neuroprotective effect against cerebral ischemia injury. Lig4-4 can be used in studies related to cerebral ischemia.
-
L-364,373 (Standard)
0 ImagesCat. No.: HY-108591RCAS No.: 103342-82-1Synonyms: R-L3 (Standard)L-364,373 (Standard) is the analytical standard of L-364,373 (HY-108591). This product is intended for research and analytical applications. L-364,373 (R-L3) is a voltage-gated Kv7.1 (KCNQ1)/mink channels activator. L-364,373 activates Iks (slow delayed rectifier potassium current) and shortens action potential duration in guinea pig cardiac myocytes, and suppresses early afterdepolarizations in rabbit ventricular myocytes.
-
Phe-Met-Arg-Phe, amide
0 ImagesCat. No.: HY-P0249CAS No.: 64190-70-1Phe-Met-Arg-Phe, amide dose dependently (ED50=23 nM) activates a K+ current in the peptidergic caudodorsal neurons.
-
Myomodulin
0 ImagesCat. No.: HY-P0268CAS No.: 110570-93-9Myomodulin is a neuropeptide present in molluscs, insects, and gastropods.
-
KRN4884
0 ImagesCat. No.: HY-U00201CAS No.: 152802-84-1KRN4884 is a K+ channel opener. In the presence of intracellular ATP (1 mM), KRN4884 (0.1-3 μM) activates KATP channels in a concentration-dependent manner (EC50=0.55 μM).
-
CS476
0 ImagesCat. No.: HY-U00211CAS No.: 41177-35-9Synonyms: NSC302998CS476 is a potent hypoglycaemic agent.
-
Potassium Channel Activator 1
0 ImagesPotassium Channel Activator 1 ((2,4-Dimethyl-6-morpholin-4-yl-pyridin-3-yl)-carbamic acid benzyl ester) is a potassium channel activator. Potassium Channel Activator 1 can be used for the study diseases or symptoms of dopaminergic system disorders.
-
U89232
0 ImagesCat. No.: HY-U00173CAS No.: 134017-78-0U-89232 appears to be a cardioselective KATP channel opener.
