Ras
Ras is the name given to a family of related proteins which is ubiquitously expressed in all cell lineages and organs. All Ras protein family members belong to a class of protein called small GTPase, and are involved in transmitting signals within cells. Ras is the prototypical member of the Ras superfamily of proteins, which are all related in 3D structure and regulate diverse cell behaviours. When Ras is 'switched on' by incoming signals, it subsequently switches on other proteins, which ultimately turn on genes involved in cell growth, differentiation and survival. As a result, mutations in ras genes can lead to the production of permanently activated Ras proteins. This can cause unintended and overactive signalling inside the cell, even in the absence of incoming signals. Because these signals result in cell growth and division, overactive Ras signaling can ultimately lead to cancer. The 3 Ras genes in humans (HRAS,KRAS, and NRAS) are the most common oncogenes in human cancer; Ras inhibitors are being studied as a treatment for cancer, and other diseases with Ras overexpression.
Ras Isoform Specific Products
All Product Categories
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Ras Related Products (720)
Related Products (720)
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Antibodies (36)
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Ras Isoform Comparison
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UC-857993
0 ImagesCat. No.: HY-124514CAS No.: 487001-04-7
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α,δ-NAG
0 ImagesCat. No.: HY-178978CAS No.: 3051899-13-6α,δ-NAG is an orally active glutaminase-resistant less-hydrolyzable L-Glutamine derivative. α,δ-NAG is a G protein-coupled receptor (GPCR) allosteric modulator. α,δ-NAG suppresses neutrophilic airway inflammation by activating the GPCR/ERK/MKP-1 pathway. α,δ-NAG can be used for the researches of inflammation and immunology, such as asthma.
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KRAS G12D modulator-1
0 ImagesCat. No.: HY-153555CAS No.: 2883034-05-5KRAS G12D modulator-1 (compound 6) is a potent KRAS G12D modulator with IC50 values of 1-10 μM for NEA-G12D, PPI-G12D, and p ERK-AGS, respectively. KRAS G12D modulator-1 can be used in research of cancer.
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KRAS G12C inhibitor 43
0 ImagesCat. No.: HY-142945CAS No.: 2648808-69-7KRAS G12C inhibitor 43 (compound 59) is a potent KRAS G12C inhibitor. KRAS G12C inhibitor 43 shows antimigration and anti-proliferative activity with IC50s of 0.001-1 µM, >1 µM, >1 µM for H358, A549, HCC cells ,respectively.
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KRAS G12C inhibitor 69
0 ImagesCat. No.: HY-170550KRAS G12C inhibitor 69 (Compound K09) is the inhibitor for mutant RAS protein KRASG12C with an IC50 of 4.36 nM. KRAS G12C inhibitor 69 inhibits the ERK phosphorylation in NCI-H358 and MIA-PACA-2 with an IC50 of 12 nM and 7 nM. KRAS G12C inhibitor 69 inhibits the proliferation of cancer cell NCI-H358 and MIA-PACA-2 with IC50 of 3.15 nM and 2.33 nM.
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KRAS-IN-41
0 ImagesCat. No.: HY-173329CAS No.: 3056974-50-3
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KRAS G12C-IN-79
0 ImagesCat. No.: HY-183645CAS No.: 3088522-27-1
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KRAS-IN-51
0 ImagesCat. No.: HY-186024CAS No.: 3076211-50-9KRAS-IN-51 (Compound 597a) is a KRas G12V inhibitor, with its IC50 for KRas G12V being 2.9 nM; KD values are 17 (at 20°C) and 68 (at 37°C) nM. KRAS-IN-51 inhibits the phosphorylation of pERK. KRAS-IN-51 has anti-proliferative activity against SW620 and MIAPaCa-2. KRAS-IN-51 can be used for research on colorectal cancer and pancreatic cancer.
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SOS1-IN-4
0 ImagesCat. No.: HY-145047CAS No.: 2738392-83-9SOS1-IN-4 is a potent SOS1 inhibitor with an IC50 of 56 nM for KRAS-C12C/SOS1 interaction (WO2021228028 A1, example 65).
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KRAS G12C inhibitor 50
0 ImagesCat. No.: HY-147631CAS No.: 2760354-12-7KRAS G12C inhibitor 50 (Example 4) is a KRAS G12C inhibitor with an IC50 of 46.7 nM.
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KRAS-IN-47
0 ImagesCat. No.: HY-179253CAS No.: 3079342-05-2KRAS-IN-47 is a KRAS inhibitor with IC50 < 50 nM against KRAS G12V. KRAS-IN-47 can be used for the study of cancers.
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KRAS G12D inhibitor 28
0 ImagesCat. No.: HY-172626CAS No.: 2923669-28-5KRAS G12D inhibitor 28 is a KRASG12D inhibitor. KRAS G12D inhibitor 28 can be used in the cancer research.
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KRAS G12C inhibitor 55
0 ImagesCat. No.: HY-147636CAS No.: 2508134-76-5KRAS G12C inhibitor 55 (Compound 1) is a KRAS G12C inhibitor.
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KRAS G12C inhibitor 51
0 ImagesCat. No.: HY-147632CAS No.: 2762632-78-8KRAS G12C inhibitor 51 (example 1) is a KRAS G12C inhibitor.
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SML-8-73-1
0 ImagesCat. No.: HY-19315CAS No.: 1536470-92-4SML-8-73-1 is a nucleotide-based KRASG12C inhibitor. SML-8-73-1 can be used for the study of non-small cell lung cancer (NSCLC).
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Rac1 Inhibitor F56, control peptide TFA
0 ImagesCat. No.: HY-P1383ARac1 Inhibitor F56, control peptide TFA is a peptide containing residues 45-60 of Rac1. Rac1 Inhibitor F56, control peptide TFA contains a Trp56 to Phe56 mutation. Rac1 Inhibitor F56, control peptide TFA has no effect on Rac1 interaction with its guanine nucleotide exchange factors (GEFs).
