α,δ-NAG
α,δ-NAG is an orally active glutaminase-resistant less-hydrolyzable L-Glutamine derivative. α,δ-NAG is a G protein-coupled receptor (GPCR) allosteric modulator. α,δ-NAG suppresses neutrophilic airway inflammation by activating the GPCR/ERK/MKP-1 pathway. α,δ-NAG can be used for the researches of inflammation and immunology, such as asthma.
For research use only. We do not sell to patients.
- CAS No.: 3051899-13-6
- Formula: C9H14N2O5
- Molecular Weight:230.22
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:OVA-induced asthma C57BL/6 mice (female, 7-8 weeks old)[1]
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Dosage:50, 100 and 200 μg/kg
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Administration:Oral gavage
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Result:Inhibited airway neutrophil and eosinophil infiltration.
Reduced the levels of TNF-α, IL-1β (Th1 cytokines) and IL-4, IL-5 (Th2 cytokines) in lung tissue.
Improved airway hyperresponsiveness (AHR).
Decreased mucus secretion and lung tissue inflammation.
Chemical Information
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CAS No. 3051899-13-6
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Molecular Weight 230.22
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Formula C9H14N2O5
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SMILES
O=C(NC(C)=O)CC[C@H](C(O)=O)NC(C)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
α,δ-NAG Related Classifications
HY-178978 Related Classifications
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