Renin
Renin is a monospecific enzyme that catalyzes the rate-limiting step in the synthesis of angiotensin II. Amplified enzymatic activity and additional physiological effects occur when renin and pro-renin bind to the (pro)renin receptor. The classical site of renin expression and secretion is the renal juxtaglomerular cell, where its expression is tightly regulated by physiological cues.
Prorenin and renin bound to the (pro)renin receptor not only increase the catalytic conversion of angiotensinogen to angiotensin I (Ang I), but also upregulate the expression of profibrotic genes. Renin plays a critical role in the regulation of blood pressure, electrolyte homeostasis, mammalian renal development, and progression of fibrotic/hypertrophic diseases. Renin inhibitors represent an alternative to angiotensin-converting enzyme inhibitors (ACEI) for the treatment of hypertension.
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Renin Related Products (78)
Related Products (78)
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SQ 31844
0 ImagesCat. No.: HY-118185CAS No.: 115766-42-2SQ 31844 is a novel renin inhibitor belonging to the imidazolidinol class. This compound, which contains an imidazole ring in its active site binding group, has potent in vitro inhibition of primate renin, but not rat, pig, or dog renin. In conscious, sodium-deprived cynomolgus monkeys, both compounds produced dose-related inhibition of plasma renin activity (PRA) over a dose range of 0.001 to 1.0 μmol/kg, administered intravenously, with complete inhibition observed at the highest dose. However, a reduction in blood pressure was only observed when 10 μmol/kg was administered intravenously or by infusion. In sodium-replete monkeys, SQ 30774 inhibited the increase in arterial blood pressure and PRA following administration of exogenous monkey renin. When the compounds were administered orally at 50 μmol/kg, only SQ 31844 significantly inhibited PRA (80%). In summary, the imidazolidinol renin inhibitors have potent inhibitory effects on renin in vitro and inhibit PRA and reduce arterial blood pressure in vivo.
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SQ 33800
0 ImagesCat. No.: HY-105503CAS No.: 138447-68-4SQ 33800 is a potent inhibitor of human renin with an IC50 of 0.35 nM. SQ 33800 can be used for the research of cardiovascular disease.
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Renin IN-2
0 ImagesCat. No.: HY-153515CAS No.: 2109805-77-6Renin IN-2 (compound 27) is an orally active human renin inhibitor with an IC50 of 0.059 μM. Renin IN-2 can be used in the research of hypertension.
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Bopindolol
0 ImagesCat. No.: HY-B1562CAS No.: 62658-63-3Synonyms: (±)-BopindololBopindolol ((±)-Bopindolol) is an orally active antagonist of β-adrenoceptors (ARs) with partial agonist activity. Bopindolol is non-selective for β1- and β2-ARs and has low affinity for β3-AR subtype. Bopindolol has intrinsic sympathomimetic as well as membrane stabilizing actions, inhibits renin secretion, and interacts with 5-HT receptors. Bopindolol is a proagent of Pindolol (HY-B0982). Bopindolol can be used for essential and renovascular hypertension research.
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EMD 55068
0 ImagesCat. No.: HY-P2075CAS No.: 126784-34-7EMD 55068 is a renin antagonist. EMD 55068 inhibits the uptake of taurocholate.
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Renin-IN-4
0 ImagesCat. No.: HY-105390CAS No.: 85139-12-4Renin-IN-4 is a Renin inhibitor. Renin-IN-4 can be used for the research of cardiovascular disease.
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Ciprokiren
0 ImagesCat. No.: HY-177326CAS No.: 143631-62-3Synonyms: Ro 44-9375Ciprokiren (Ro 44-9375) is a Renin inhibitor with IC50s of 0.07 and 0.65 nM for hRenin in buffer and plasma, respectively. Ciprokiren be applied transdermally with similar hemodynamic effects without decrease of plasma renin activity or plasma immunoreactive angiotensin II. Ciprokiren has antihypertensive efficacy and can be used for hypertension research.
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VTP-27999
0 ImagesCat. No.: HY-50768CAS No.: 942142-51-0VTP-27999 is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
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CGP 29287
0 ImagesCat. No.: HY-P2147CAS No.: 93287-54-8Synonyms: Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Lys(Boc)-OmeCGP 29287 is a specific renin inhibitor.
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CP-85339
0 ImagesCat. No.: HY-P2024CAS No.: 119625-53-5CP-85339 is a tetrapeptide renin inhibitor.
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Imarikiren
0 ImagesCat. No.: HY-109034CAS No.: 1202265-63-1Synonyms: AK-272 free base; SCO-272 free baseImarikiren (AK-272 free base) is an orally active, selective Renin inhibitor with an IC50 value of 2.1 nM against h-Renin. Imarikiren blocks the conversion of Angiotensinogen to Angiotensin I and reduces mean arterial pressure by inhibiting Angiotensin II that binds to AT1. Imarikiren alleviates myocardial hypertrophy and pulmonary congestion, exerting cardioprotective effects. Imarikiren can be used in research related to hypertension and heart failure.
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Terlakiren
0 ImagesCat. No.: HY-105205CAS No.: 119625-78-4Synonyms: CP-80,794Terlakiren (CP-80,794) is an orally active inhibitor of renin. Terlakiren inhibits the efficacy of human renin with an IC50 value of 0.7 nM. Terlakiren has potential applications in hypertension.
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L-363564
0 ImagesCat. No.: HY-P2097CAS No.: 86153-46-0L-363564 is a renin inhibitor. L-363564 can be used in cardiovascular disease related research.
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CGP 44099
0 ImagesCat. No.: HY-P2060CAS No.: 128856-81-5CGP 44099 is a renin inhibitor. CGP 44099 can be used to study the ischemic injury and reperfusion arrhythmias in rat hearts.
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Aliskiren-d6 hydrochloride
0 ImagesCat. No.: HY-12176ASCAS No.: 1246815-96-2Synonyms: CGP 60536 D6 Hydrochloride; CGP60536B D6 Hydrochloride; SPP 100 D6 HydrochlorideAliskiren-d6 (hydrochloride) is is deuterium labeled Aliskiren, which is a direct renin inhibitor.
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H-77
0 ImagesCat. No.: HY-P2647CAS No.: 82131-82-6H-77 is a selective Renin inhibitor with an IC50 of 1.2 μM. H-77 causes dose-dependent decreases in plasma angiotensin I, plasma angiotensin II, and mean arterial pressure in sodium-depleted conscious beagle dogs. H-77 does not alter blood pressure or plasma angiotensin II levels in conscious chronically cannulated rats. H-77 can be used in studies related to the physiological and pathological states of the renin-angiotensin system.
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SR 42128
0 ImagesCat. No.: HY-P2130CAS No.: 98092-14-9SR 42128 is a potent renin inhibitor. SR 42128 potently inhibits primate renins whereas other animal renins are much less inhibited.
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Renin inhibitor peptide,rat
0 ImagesCat. No.: HY-P5388CAS No.: 115290-00-1
