Wee1
Wee1 is a nuclear kinase belonging to the Ser/Thr family of protein kinases in the fission yeast Schizosaccharomyces pombe (S. pombe). Wee1 has amolecular mass of 96 kDa and it is a key regulator of cell cycle progression. Wee1 influences cell size by inhibiting the entry into mitosis, through inhibiting Cdk1. Wee1 has homologues in many other organisms, including mammals. Wee1 inhibits Cdk1 by phosphorylating it on two different sites, Tyr15 and Thr14. Cdk1 is crucial for the cyclin-dependent passage of the various cell cycle checkpoints. At least three checkpoints exist for which the inhibition of Cdk1 by Wee1 is important: G2/M checkpoint, Cell size checkpoint, DNA damage checkpoint. Wee1 is shown to phosphorylate histone H2B at tyrosine 37 residue which regulates global expression of histones.
WEE1 subfamily includes PMYT1.
WEE1 subfamily includes PMYT1.
Wee1 Isoform Specific Products
All Product Categories
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Wee1 Related Products (83)
Related Products (83)
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Wee1 Isoform Comparison
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WEE1-IN-4 (Standard)
0 ImagesCat. No.: HY-108343RCAS No.: 622855-37-2
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Sirusertib
0 ImagesCat. No.: HY-188057CAS No.: 3066062-53-8Sirusertib (WEE1A&Myt1-IN-1) is a dual Wee1A/Myt1 inhibitor, with an IC50 of ≤10 nM against Wee1A and ≤20 nM against Myt1. Sirusertib is applicable for cancer-related research.
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PKMYT1-IN-4
0 ImagesCat. No.: HY-162986CAS No.: 3047617-07-9PKMYT1-IN-4 (compund 27) is a PKMYT1 inhibitor with IC50 less than 50 nM.
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lunresertib (Standard)
0 ImagesCat. No.: HY-145817ARCAS No.: 2719793-90-3Synonyms: RP-6306 (Standard)lunresertib (Standard) is the analytical standard of lunresertib (HY-145817A). This product is intended for research and analytical applications. lunresertib (RP-6306) is a potent, selective and orally active PKMYT1 inhibitor with an IC50 of 14 nM. lunresertib shows a high degree of selectivity over other Kinases in cellular binding assays. lunresertib shows anticancer effects.
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PKMYT1-IN-7
0 ImagesCat. No.: HY-159937CAS No.: 2986404-30-0PKMYT1-IN-7 (compound 7) is an orally active PKMYT1 inhibitor with IC50 values of 1.6 nM and 0.06 μM against of PKMYT1 and pCDK1, respectively. PKMYT1-IN-7 suppresses the phosphorylation of CDK1 at T14 and Y15. PKMYT1-IN-7 shows anticancer activity both< and <.
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Myt1-IN-6
0 ImagesCat. No.: HY-176853CAS No.: 3056083-14-5Myt1-IN-6 (Compound formula (1)) is a highly selective MYT1 kinase inhibitor. Myt1-IN-6 is promising for research of RB1-deficient cancers (e.g., triple-negative breast cancer).
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PKMYT1-IN-14
0 ImagesCat. No.: HY-184405PKMYT1-IN-14 is an allosteric, mixed ATP-competitive and non-competitive PKMYT1 inhibitor with an IC50 of 56.2 μM. PKMYT1-IN-14 is applicable to research related to breast cancer, gastric cancer, non-small cell lung cancer, and clear cell renal cell carcinoma.
