2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Carbonyl Reductase
  5. Carbonyl Reductase Inhibitor

Carbonyl Reductase Inhibitor

Carbonyl Reductase Isoform Comparison

Carbonyl Reductase Inhibitors (6):

Cat. No. Product Name Effect Purity
  • HY-115510
    SPR inhibitor 3
    		Inhibitor 99.01%
    SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels.
  • HY-155587
    Hydroxy-PP
    		Inhibitor 99.66%
    Hydroxy-PP is a potent carbonyl reductase 1 (CBR1) inhibitor with an IC50 value of 0.78 μM. Hydroxy-PP also potently inhibits the cytoplasmic tyrosine kinase Fyn with an IC50 value of 5 nM.
  • HY-121710
    MonoHER
    		Inhibitor
    MonoHER (7-Monohydroxyethylrutoside) is a Carbonyl reductase 1 (CBR1) inhibitor and can be used as a cardioprotective agent. MonoHER inhibits the activity of CBR1 V88 and CBR1 I88 in a concentration-dependent manner.
  • HY-157451
    CBR1-IN-7
    		Inhibitor
    CBR1-IN-7 (Compound JV-2) is a human CBR1 inhibitor (IC50=8 μM). CBR1-IN-7 can be used in cancer research.
  • HY-157452
    (8S)-Methyl zearalenone
    		Inhibitor
    (8S)-Methyl zearalenone (ZEA analogue 5) is a selective CBR1 (carbonyl reductase 1) inhibitor, with an IC50 of 0.21 μM.
  • HY-157447
    CBR1-IN-4
    		Inhibitor
    CBR1-IN-4 (Compound 13p) is a human carbonyl reductase 1 (CBR1) inhibitor (IC50=0.09 μM). CBR1-IN-4 can be used in cancer research.