Carbonyl Reductase Inhibitor
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SPR inhibitor 3
0 ImagesSynonyms: SPRi3SPR inhibitor 3 (SPRi3) is a potent sepiapterin reductase (SPR) inhibitor. SPR inhibitor 3 (SPRi3) displays high binding affinity to human SPR in a cell-free assay (IC50=74 nM) and efficiently reduces biopterin levels in a cell-based assay (IC50=5.2 μM). SPR inhibitor 3 (SPRi3) reduces neuropathic and inflammatory pain through a reduction of BH4 levels.
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Hydroxy-PP
0 ImagesHydroxy-PP is a potent carbonyl reductase 1 (CBR1) inhibitor with an IC50 value of 0.78 μM. Hydroxy-PP also potently inhibits the cytoplasmic tyrosine kinase Fyn with an IC50 value of 5 nM.
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MonoHER
0 ImagesCat. No.: HY-121710CAS No.: 23869-24-1Synonyms: 7-MonohydroxyethylrutosideMonoHER (7-Monohydroxyethylrutoside) is a Carbonyl reductase 1 (CBR1) inhibitor and can be used as a cardioprotective agent. MonoHER inhibits the activity of CBR1 V88 and CBR1 I88 in a concentration-dependent manner.
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CBR1-IN-7
0 ImagesCat. No.: HY-157451CAS No.: 1119826-35-5
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(8S)-Methyl zearalenone
0 ImagesCat. No.: HY-157452CAS No.: 1137720-39-8(8S)-Methyl zearalenone (ZEA analogue 5) is a selective CBR1 (carbonyl reductase 1) inhibitor, with an IC50 of 0.21 μM.
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CBR1-IN-4
0 ImagesCat. No.: HY-157447CAS No.: 1798284-64-6CBR1-IN-4 (Compound 13p) is a human carbonyl reductase 1 (CBR1) inhibitor (IC50=0.09 μM). CBR1-IN-4 can be used in cancer research.
