CD73 Inhibitor

CD73-IN-21 (Compound 12f) is an Ecto-5′-nucleotidase (CD73) inhibitor with K_is of 20 and 302  nM for hCD73 and mCD73, respectively. CD73-IN-21 can be used for cancers like breast cancer research.

BC-010 is a human monoclonal antibody (mAb) targeting NT5E/CD73. BC-010 can be used in the study of tumors.

IPH5301 is a human IgG1 monoclonal antibody (mAb) targeting NT5E/CD73. IPH5301 has a functionally silent Fc domain, specifically inhibits soluble and membrane CD73 enzyme activity, and restores the proliferation of immune T cells. IPH5301 can be used in anti-tumor immunity research. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001).

PSB-12379 (Standard) is the analytical standard of PSB-12379 (HY-100747). This product is intended for research and analytical applications. PSB-12379, a nucleotide analogue, is a potent Ecto-5'-Nucleotidase (CD73) inhibitor with Kis of 9.03 nM (rat) and 2.21 nM (human).

CD73-IN-1 (Standard) is the analytical standard of CD73-IN-1 (HY-103695). This product is intended for research and analytical applications. CD73-IN-1 is an inhibitor of CD73 which can be used in the treatment of cancer extracted from patent WO 2017153952 A1, example 80.

BMS-986179 is a human monoclonal antibody (mAb) targeting NT5E/CD73. BMS-986179 inhibits CD73 enzymatic activity in tumor vasculature and tumor cells. BMS-986179 can be used in advanced solid tumors research.

MethADP disodium is a specific CD73 inhibitor.