Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Inhibitors
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Drug Derivative Related Products (4014)
Related Products (4014)
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Ataprost
0 ImagesCat. No.: HY-119860CAS No.: 83997-19-7Synonyms: ONO 41483Ataprost (ONO 41483) is an orally active Carboprostacyclin (HY-112322) analogue. Ataprost exhibits 2.6 times more active than Carboprostacyclin in inhibiting ADP-induced platelet aggregation in vitro. Ataprost has the ability to relieve coronary spasm.
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trans-Coniferyl acetate
0 ImagesCat. No.: HY-N16749CAS No.: 94930-81-1trans-Coniferyl acetate is a natural phenylacetylene.
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Zolazepam
0 ImagesCat. No.: HY-119146CAS No.: 31352-82-6Synonyms: CI-716 free baseZolazepam (CI-716 free base) is a benzodiazepine derivative with anxiolytic and anticonvulsant properties. Zolazepam combined with Tiletamine causes a decrease in ventilation, resulting in the development of respiratory acidosis. Zolazepam can be used as sedative and muscle relaxants.
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Symplocosidin
0 ImagesCat. No.: HY-N17320CAS No.: 76549-34-3Symplocosidin is a natural product that can be found in Symplocos sumuntia?Buch.-Ham. ex D. Don.
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Lamivudine triphosphate
0 ImagesCat. No.: HY-131603CAS No.: 143188-53-8Synonyms: 3TCTPLamivudine triphosphate (3TCTP) is a phosphorylated Lamivudine (HY-B0250) (a nucleoside analogue). Lamivudine triphosphate inhibits the reverse transcriptase of HIV or HBV viruses to block viral replication by chain termination. Lamivudine triphosphate is also an inhibitor of the RdRp activity of the NS5B subunit of the HCV. Lamivudine triphosphate can be incorporated into the nascent RNA by the SARS-CoV-2 RdRp, thus halting mutations in the nascent SARS-CoV-2 RNA.
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(E)-5-Hydroxy-6-isoprenyl-2-(pent-1-en-1-yl)benzofuran-4-carbaldehyde
0 ImagesCat. No.: HY-N17161CAS No.: 916602-30-7(E)-5-Hydroxy-6-isoprenyl-2-(pent-1-en-1-yl)benzofuran-4-carbaldehyde is a natural phenolic compound.
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(5β)-3,12-Dioxocholan-24-oic acid
0 ImagesCat. No.: HY-W749329CAS No.: 2958-05-6(5β)-3,12-Dioxocholan-24-oic acid is a natural product that can be found in animal bile.
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epi-Smilagenin
0 ImagesCat. No.: HY-106353ACAS No.: 16653-88-6epi-Smilagenin is a 5β-spirostan-3α-ol and steroidal sapogenin. epi-Smilagenin can be found in the rumen content of sheep intoxicated by Brachiaria decumbens.
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7-Demethoxylophorine
0 ImagesCat. No.: HY-N17313CAS No.: 1187303-46-37-Demethoxylophorine is a natural product that can be found in mistletoe.
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8-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione
0 ImagesCat. No.: HY-N9307CAS No.: 76475-32-68-Acetoxy-15,16-epoxy-8,9-secolabda-13(16),14-diene-7,9-dione is a natural diterpene.
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Cholic acid-Cit
0 ImagesCholic acid-Cit is a citrinate-conjugated form of Cholic acid (HY-N0324). Cholic acid-Cit can be used in studies related to Crohn's disease.
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1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC
0 ImagesCat. No.: HY-165030CAS No.: 154436-51-8Synonyms: 15(S)-HETE-SAPC; 15(S)-Hydroxyeicostetraenoic acid-SAPC; 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-phosphatidylcholine1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PC is an active compound.
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2′,3′-O-Diacetyl-3-O-α-L-arabinopyranosyl-23-hydroxyolea-12-en-28-oic acid
0 ImagesCat. No.: HY-N17545CAS No.: 861886-94-42′,3′-O-Diacetyl-3-O-α-L-arabinopyranosyl-23-hydroxyolea-12-en-28-oic acid is a natural product that can be found in hedera nepalensis?var.?sinensis?(tobl.) rehd.
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26-Degluco-torvoside H
0 ImagesCat. No.: HY-N18350CAS No.: 437988-00-626-Degluco-torvoside H (Compound 4) is a Furostanol glycoside derivative. 26-Degluco-torvoside H forms via hydrolysis of Torvoside H by β-glucosidase from Solanum torvum leaves.
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Etiguanfacine
0 ImagesCat. No.: HY-16778CAS No.: 1346686-31-4Etiguanfacine is a derivative of Guanfacine (HY-17416A). Etiguanfacine can be used for research to reduce the gastrointestinal side effects of Guanfacine.
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Plantagiolide B
0 ImagesCat. No.: HY-N16869CAS No.: 913263-85-1Plantagiolide B is a natural steroid.
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4-(Acetoxymethyl)phenyl glucoside
0 ImagesCat. No.: HY-N16538CAS No.: 188290-72-44-(Acetoxymethyl)phenyl glucoside is a type of gastrodin derivative that can cross the blood-brain barrier. 4-(Acetoxymethyl)phenyl glucoside exhibits sedative, anticonvulsant and analgesic effects in mouse models. 4-(Acetoxymethyl)phenyl glucoside can be used for research on senile cardiovascular and cerebrovascular diseases as well as brain nerve disorders.
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WAY-620521
0 ImagesCat. No.: HY-W674261CAS No.: 315693-33-5WAY-620521 is an active molecule.
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L 681217
0 ImagesCat. No.: HY-119012CAS No.: 93522-10-2L 681217 is an active compound.
