Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4021)
Related Products (4021)
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Ornithine-methotrexate
0 ImagesCat. No.: HY-115850CAS No.: 80407-73-4Ornithine-methotrexate is an active compound.
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Dibromochloroacetaldehyde
0 ImagesCat. No.: HY-133649CAS No.: 64316-11-6Dibromochloroacetaldehyde belongs to trihalogenated acetaldehyde and is a byproduct in drinking water. Dibromochloroacetaldehyde has genotoxicity.
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Physaminimin C
0 ImagesCat. No.: HY-N13789CAS No.: 1582259-03-7Physaminimin C is a natural steroid.
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Dodovisone A
0 ImagesCat. No.: HY-N16885CAS No.: 1616683-50-1Dodovisone A is a natural flavonoid.
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(3β,5α)-Androstan-3-amine hydrochloride
0 ImagesCat. No.: HY-122084CAS No.: 54156-23-9(3β,5α)-Androstan-3-amine (hydrochloride) is an active compound.
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3,5-O-Dicaffeoyl-1-O-methylquinic acid methyl ester
0 ImagesCat. No.: HY-N17534CAS No.: 409361-62-23,5-O-Dicaffeoyl-1-O-methylquinic acid methyl ester is a Caffeoylquinic acid derivative. 3,5-O-Dicaffeoyl-1-O-methylquinic acid methyl ester can be isolated from Aster tataricus. 3,5-O-Dicaffeoyl-1-O-methylquinic acid methyl ester does not inhibit LPS-induced nitric oxide production.
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Acoraminol A
0 ImagesCat. No.: HY-N15714CAS No.: 1342797-57-2Acoraminol A is one of the stereoisomers of phenylpropanoids, the other of which is Acoraminol B (HY-N15715), which can be isolated from the methanol extract of the rhizome of Acorus tatarinowii. Acoraminol A has weak cytotoxic effects on several human tumor cell lines (IC50>30 μM).
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ZIMET 124/73
0 ImagesCat. No.: HY-123168CAS No.: 61930-46-9ZIMET 124/73 is a hetarylhydrazone derivative. ZIMET 124/73 is a potent antiviral agent. ZIMET 124/73 can be used for Mengo virus research.
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Isoxepac-d6
0 ImagesCat. No.: HY-W050088SCAS No.: 2012598-71-7Synonyms: HP 549-d6Isoxepac-d6 (HP 549-d6) is the deuterium labeled Isoxepac (HY-W050088). Isoxepac (HP 549) is an orally active non-steroidal anti-inflammatory agent. Isoxepac can inhibit Carrageenan (HY-125474) paw oedema, adjuvant-induced polyarthritis, and prostaglandin synthesis. Isoxepac (200 mg) has an analgesic effect after meniscectomy with a low incidence of side effects. Isoxepac can be used in the research of inflammatory (rheumatoid arthritis) and pain-related diseases.
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Homofukinolide
0 ImagesCat. No.: HY-N21780CAS No.: 41059-96-5Homofukinolide is a bakkenolide-type sesquiterpenoid found in the rhizomes of Petasites tatewakianus Kitam and can serve as a marker for plant quality evaluation.
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Methyl cis-15-tetracosenoate
0 ImagesSynonyms: Methyl nervonate; Methyl (Z)-tetracos-15-enoate; Nervonic acid methyl esteMethyl cis-15-tetracosenoate (Methyl nervonate; Methyl (Z)-tetracos-15-enoate; Nervonic acid methyl ester) is the methyl ester form of nervonic acid (Nervonic acid, HY-N2526). Nervonic acid is an orally active monounsaturated fatty acid. Nervonic acid exerts anti-inflammatory activity by inhibiting the NF-κB signaling pathway. Nervonic acid can be used in the research of neurodegenerative diseases.
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(+)-Epinortrachelogenin
0 ImagesCat. No.: HY-N10909CAS No.: 124988-62-1(+)-Epinortrachelogenin is a natural lignan.
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DL-Methionine Sulfone
0 ImagesCat. No.: HY-W141863CAS No.: 820-10-0DL-Methionine Sulfone is a Methionine (HY-13694) derivative.
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Antiproliferative agent-40
0 ImagesCat. No.: HY-156879CAS No.: 871837-59-1Antiproliferative agent-40 (Compound 9) inhibits proliferation of HT1080 and MCF-7 with IC50s of 52 and 8.2 μM respectively.
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Adenostemmoic acid D
0 ImagesCat. No.: HY-N13573CAS No.: 130217-20-8Adenostemmoic acid D is a natural diterpene.
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KCO912
0 ImagesCat. No.: HY-120043CAS No.: 185695-83-4KCO912 is an active compound.
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3,4,5-Trihydroxyallylbenzene 3,4-di-O-glucoside
0 ImagesCat. No.: HY-N13764CAS No.: 2172431-63-73,4,5-Trihydroxyallylbenzene 3,4-di-O-glucoside is a natural phenylacetylene.
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MNI-caged-L-glutamate TFA
0 ImagesCat. No.: HY-107520ACAS No.: 2226362-29-2MNI-caged-L-glutamate TFA is an inert photolabile glutamate precursor. MNI-caged-L-glutamate TFA does not modulate NMDA and AMPA receptor function in cultured neurones. MNI-caged-L-glutamate TFA can be used for research on neurotransmitters.
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Liquiridiolic acid
0 ImagesCat. No.: HY-N13820CAS No.: 20528-70-5Liquiridiolic acid is a natural triterpene.
