Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4032)
Related Products (4032)
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BASF 43915
0 ImagesCat. No.: HY-19597CAS No.: 91587-01-8Synonyms: ORF 18704; RWJ 18704BASF 43915 (Pelretin) is a Phenyl analog.
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Astaxanthin dipalmitate
0 ImagesCat. No.: HY-W750672CAS No.: 112421-21-3Astaxanthin dipalmitate is a carotenoid. Astaxanthin dipalmitate can be used for pigmentation of rainbow trout and sea trout. Carotenoids are important biological active, and may regulate cellular differentiation, growth control, photooxidative protection, cell membrane stability, photosynthesis, vision process and nutrition.
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Azithromycin-amide-C3-amide-quinoxaline
0 ImagesCat. No.: HY-180767Azithromycin-amide-C3-amide-quinoxaline (Compound 5f) is an Azithromycin (HY-17506) derivative and antibacterial agent. Azithromycin-amide-C3-amide-quinoxaline inhibits topoisoisomerase I with an IC50 of 120.7 μM. Azithromycin-amide-C3-amide-quinoxaline interacts with 70S E. coli ribosome with a Kd of 0.8 nM. Azithromycin-amide-C3-amide-quinoxaline inhibits bacterial translation with an IC50 of 0.7 μM. Azithromycin-amide-C3-amide-quinoxaline shows antibacterial potency against S. pneumonia ATCC 49619, S. aureus ATCC 29213, E. faecalis ATCC 29212 with MICs of 0.06 μg/mL, 2 μg/mL, 0.5 μg/mL, respectively. Azithromycin-amide-C3-amide-quinoxaline exhibits anticancer activity against prostate cancer, colon cancer.
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Rose oxide
0 ImagesRose oxide is a kind of monoterpenoid volatile organic compound with a distinctive rose fragrance. However, rose oxide does not have inhibitory activity against the formation of breast cancer stem cells.
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1(R)-Tetrahydrocannabidiol
0 ImagesCat. No.: HY-172751CAS No.: 3061058-81-6Synonyms: trans-H4CBD1(R)-Tetrahydrocannabidiol (Compound 4) is a drug derivative that can be used in research on neurological diseases.
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2-(Carbamimidoylsulfanyl)acetic acid hydrochloride
0 ImagesCat. No.: HY-W281950CAS No.: 5425-78-52-(Carbamimidoylsulfanyl)acetic acid hydrochloride is a thiourea compound and an Isothiourea derivative, with potential antidiabetic activity.
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Theleganbanin B
0 ImagesCat. No.: HY-N15564CAS No.: 31554-34-4Theleganbanin B is a p-terphenyl derivative found in the Thelephora ganbajun. Theleganbanin B inhibits TNF-α, IL-6, and IL-1β production in LPS-induced BV-2 microglial cells. Theleganbanin B inhibits the phosphorylation of JAK2/STAT3. Theleganbanin B is promising for research of neurodegenerative diseases .
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Methyl 2-phenyl-2-(pyrrolidin-1-yl)acetate hydrochloride
0 ImagesCat. No.: HY-W725181CAS No.: 27594-60-1Methyl 2-phenyl-2-(pyrrolidin-1-yl)acetate hydrochloride is structurally similar to known stimulants.
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3-(3-Nitrophenyl)-5-phenyl-1,2,4-oxadiazole
0 ImagesCat. No.: HY-W190972CAS No.: 20844-48-83-(3-Nitrophenyl)-5-phenyl-1,2,4-oxadiazole is a PEG derivative containing a tert-butyl ester and an azide group.
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N-Deacetylcolchicine
0 ImagesN-Deacetylcolchicine is a microtubule polymerization inhibitor with an IC50 of 3 μM against bovine brain microtubules. N-Deacetylcolchicine is a derivative of Colchicine (HY-16569). N-Deacetylcolchicine can activate the GTPase activity of microtubules and can be used for the research of cancer.
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WAY-327131
0 ImagesWAY-327131 is an active molecule.
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Avocadene
0 ImagesCat. No.: HY-W753557CAS No.: 24607-08-7Avocadene is a natural product isolated from Persea americana leaves, with anticancer, insecticidal, anti-Helicobacter pylori, and anti-inflammatory activity. Avocadene exerts antibacterial and anti‑inflammatory effects by suppressing Helicobacter pylori growth and inhibiting protein denaturation. Avocadene displays obvious cytotoxic activity against human prostate cancer PC‑3 cells with an IC50 of 0.5 μg/mL. Avocadene can be used for research of Helicobacter pylori‑associated gastrointestinal inflammation, gastroduodenal injury and prostate tumors.
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9,10-Dihydrophenanthrene
0 ImagesCat. No.: HY-W016470CAS No.: 776-35-29,10-Dihydrophenanthrene is an analogue of 9,10-Phenanthrenequinone (HY-W014507). 9,10-Dihydrophenanthrene loses its anti-tumor activity that induces apoptosis in HCT-116 and HL-60 tumor cells.
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Nisobamate
0 ImagesCat. No.: HY-U00204CAS No.: 25269-04-9Synonyms: W1015Nisobamate (W1015) is a tranquilizer.
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Compound 2
0 ImagesCat. No.: HY-U00358CAS No.: 872313-42-3Compound 2 is an active compound used for the research of metabolic bone diseases.
