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Referencia número: HY-180767

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Azithromycin-amide-C3-amide-quinoxaline

Azithromycin-amide-C3-amide-quinoxaline (Compound 5f) is an Azithromycin (HY-17506) derivative and antibacterial agent. Azithromycin-amide-C3-amide-quinoxaline inhibits topoisoisomerase I with an IC₅₀ of 120.7 μM. Azithromycin-amide-C3-amide-quinoxaline interacts with 70S E. coli ribosome with a K_d of 0.8 nM. Azithromycin-amide-C3-amide-quinoxaline inhibits bacterial translation with an IC₅₀ of 0.7 μM. Azithromycin-amide-C3-amide-quinoxaline shows antibacterial potency against S. pneumonia ATCC 49619, S. aureus ATCC 29213, E. faecalis ATCC 29212 with MICs of 0.06 μg/mL, 2 μg/mL, 0.5 μg/mL, respectively. Azithromycin-amide-C3-amide-quinoxaline exhibits anticancer activity against prostate cancer, colon cancer.

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Fòrmula: C₅₁H₈₄N₆O₁₄
Peso molecular:1005.24

Almacenamiento:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (281 KB)

Azithromycin-amide-C3-amide-quinoxaline Chemical Structure

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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- IC₅₀ & Target
Chemical Information
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Bioz

Actividad biológica

Descripciòn

IC₅₀ & Target^[1]

Topoisomerase I

120.7 μM (IC₅₀)

Ver todos los productos específicos de isoformas Topoisomerase :

Chemical Information

Peso molecular 1005.24
Fòrmula C₅₁H₈₄N₆O₁₄
SMILES

C[C@H]1[C@H](OC(NCCCNC(C2=NC(C=CC=C3)=C3N=C2)=O)=O)[C@](C)(OC)C[C@H](O[C@@H]([C@H](C)[C@@H](O[C@@H]4O[C@H](C)C[C@H](N(C)C)[C@H]4O)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@](C)(O)[C@@H](CC)O5)[C@@H](C)C5=O)O1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureza y Documentación

Select Batch:

Pureza: 99.98%

Assay: 99.98%

ee.: 99.98%

Ficha de datos (281 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instrucciones de manejo (2659 KB)

Referencias

[1]. Martynov MM, et al. 4″-modified azithromycin derivatives bearing nitrogen-containing heterocycles with dual inhibitory activity. Bioorg Chem. 2025 Dec 17;169:109396. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Azithromycin-amide-C3-amide-quinoxaline

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Actividad biológica
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- IC₅₀ & Target
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Azithromycin-amide-C3-amide-quinoxaline

Ver todos los productos específicos de isoformas Topoisomerase

Actividad biológica

Chemical Information

Pureza y Documentación

Referencias

Calculators

Help & FAQs

Azithromycin-amide-C3-amide-quinoxaline Related Classifications

HY-180767 Related Classifications