24607-08-7
Chemical Structure
Avocadene
- CAS No.: 24607-08-7
- Formula:C17H34O3
- Molecular Weight:286.45
IUPAC Name: (2R,4R)-heptadec-16-ene-1,2,4-triol
InChIKey: DFEHQWFIOMAGBM-IAGOWNOFSA-N
SMILES: C=CCCCCCCCCCCC[C@@H](O)C[C@@H](O)CO
Biological Activity: Avocadene is a natural product isolated from Persea americana leaves, with anticancer, insecticidal, anti-Helicobacter pylori, and anti-inflammatory activity. Avocadene exerts antibacterial and anti‑inflammatory effects by suppressing Helicobacter pylori growth and inhibiting protein denaturation. Avocadene displays obvious cytotoxic activity against human prostate cancer PC‑3 cells with an IC50 of 0.5 μg/mL. Avocadene can be used for research of Helicobacter pylori‑associated gastrointestinal inflammation, gastroduodenal injury and prostate tumors[1][2].
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Avocadene | Avocadene is a natural product isolated from Persea americana leaves, with anticancer, insecticidal, anti-Helicobacter pylori, and anti-inflammatory activity. Avocadene exerts antibacterial and anti‑inflammatory effects by suppressing Helicobacter pylori growth and inhibiting protein denaturation. Avocadene displays obvious cytotoxic activity against human prostate cancer PC‑3 cells with an IC50 of 0.5 μg/mL. Avocadene can be used for research of Helicobacter pylori‑associated gastrointestinal inflammation, gastroduodenal injury and prostate tumors. | |||||||||||||||||||||
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- [1]. Cunha VLS. De Novo Asymmetric Synthesis of Avocadyne, Avocadene and Avocadane Stereoisomers. J Org Chem. 2019;84(21):13898-13904.
- [2]. Le TNC. Anti-Helicobacter pylori and anti-inflammatory activities of Persea americana leaf extract and its isolated avocadene: a promising natural therapeutic candidate. Nat Prod Res. 2025; Epub ahead of print.
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