3476-50-4
3476-50-4
Chemical Structure
N-Deacetylcolchicine
- CAS No.: 3476-50-4
- Formula:C20H23NO5
- Molecular Weight:357.40
IUPAC Name: (S)-7-amino-1,2,3,10-tetramethoxy-6,7-dihydrobenzo[a]heptalen-9(5H)-one
InChIKey: HFPMXDMZJUJZBX-AWEZNQCLSA-N
SMILES: COC1=C2C(C([C@H](CCC2=CC(OC)=C1OC)N)=C3)=CC=C(OC)C3=O
Biological Activity: N-Deacetylcolchicine is a microtubule polymerization inhibitor with an IC50 of 3 μM against bovine brain microtubules. N-Deacetylcolchicine is a derivative of Colchicine (HY-16569). N-Deacetylcolchicine can activate the GTPase activity of microtubules and can be used for the research of cancer[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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N-Deacetylcolchicine | 98.38% | N-Deacetylcolchicine is a microtubule polymerization inhibitor with an IC50 of 3 μM against bovine brain microtubules. N-Deacetylcolchicine is a derivative of Colchicine (HY-16569). N-Deacetylcolchicine can activate the GTPase activity of microtubules and can be used for the research of cancer. | ||||||||||||||||||||
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References
- [1]. Muzaffar, A., et al. Antitubulin effects of derivatives of 3-demethylthiocolchicine, methylthio ethers of natural colchicinoids, and thioketones derived from thiocolchicine. Comparison with colchicinoids. J. Med. Chem. 33(2), 567-571 (1990). [Content Brief]
- [2]. Lin, et al. Effects of inhibitors of tubulin polymerization on GTP hydrolysis. The Journal of Biological Chemisty 256(17), 9242-9245 (1981). [Content Brief]
Keywords
