Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4010)
Related Products (4010)
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Leukotriene E4 methyl ester
0 ImagesCat. No.: HY-W747567CAS No.: 89461-65-4Leukotriene E4 methyl ester is a methyl ester of Leukotriene E4 (HY-113465). Leukotriene E4 methyl ester can be used for the research of inflammatory diseases.
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NE58043
0 ImagesCat. No.: HY-W779743CAS No.: 105462-25-7NE58043 (Compound 21) is a nitrogen-containing bisphosphonate compound. NE58043 has no significant inhibitory activity against Entamoeba histolytica and Plasmodium falciparum with IC50 > 200 μM. NE58043 shows a LD50 of 171 μM for human nasopharyngeal carcinoma KB cells. NE58043 can be used for the research of cancer and infection, such as nasopharyngeal carcinoma.
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Hexadecyl ferulate
0 ImagesCat. No.: HY-N21799CAS No.: 64190-80-3Hexadecyl ferulate is a lipophilic C16 alkyl ferulate synthesized from ferulic acid and cetyl alcohol, possessing free radical-scavenging antioxidant activity. Hexadecyl ferulate inhibits the formation of lipid oxidation products in soybean oil during deep frying and exhibits antioxidant efficacy that increases with alkyl chain length. Hexadecyl ferulate can be used in antioxidant-related research.
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BMS-188797
0 ImagesCat. No.: HY-106185CAS No.: 172481-83-3BMS-188797 is a novel Taxane analog. BMS-188797 enhances the efficacy of radiotherapy against lung cancer.
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Hokbusine A
0 ImagesCat. No.: HY-N18254CAS No.: 86500-43-8Hokbusine A is a diterpenic alkaloid and C19 norditerpenoid (aconitine-type) alkaloid that can be found in the roots of Aconitum napellus L. (Swiss variety) and Aconitum jaluense.Hokbusine A exhibits low acute toxicity in ddY mice via intraperitoneal administration, with an LD50 value greater than 1 mg/kg.
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Platachromone B
0 ImagesCat. No.: HY-N13791CAS No.: 1606149-63-6Platachromone B is a natural phenolic compound.
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Imuracetam
0 ImagesCat. No.: HY-148604CAS No.: 67542-41-0Imuracetam is a racetam compound. Racetam compounds have good cognitive-enhancing effects.
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Diaporol I
0 ImagesCat. No.: HY-N19796CAS No.: 139343-87-6Diaporol I is a pimarane-type sesquiterpene that can be isolated from the mangrove-derived endophytic fungus Diaporthe sp.
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Bromotetrandrine
0 ImagesCat. No.: HY-121247CAS No.: 62067-29-2Synonyms: 5-Bromotetrandrine; BrTet; W198Bromotetrandrine is a potent inhibitor of P-glycoprotein (P-gp)-mediated multidrug resistance (MDR). Bromotetrandrine shows significant MDR reversal activity in vitro and in vivo, which may be related to the inhibition of P-gp overexpression and the increase in intracellular accumulation of anticancer agents. Bromotetrandrine is a brominated derivative of tetrandrine, which is promising for MDR modulator for tumor assessment.
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Phoyunbene B
0 ImagesCat. No.: HY-N9778CAS No.: 886747-62-2Phoyunbene B is a similar substance to Resveratrol (HY-16561). Phoyunbene B exhibits stronger growth inhibitory activity against human liver cancer cells HepG2 compared to Resveratrol. Phoyunbene B induces G2/M phase cell cycle arrest and apoptosis. Phoyunbene B increases Bax/Bcl-2 and activates Caspase-3. Phoyunbene B inhibits the invasion and migration of cancer cells. Phoyunbene B can be used for research on liver cancer.
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3-CEC hydrochloride
0 ImagesCat. No.: HY-172079CAS No.: 2748225-41-23-CEC hydrochloride is a drug derivative.
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Schindilactone E
0 ImagesCat. No.: HY-N7997CAS No.: 1033288-86-6Schindilactone E is a natural product that can be found in Schisandra chinensis?(Turcz.) Baill..
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(4S, 6S)-4-Hydroxypiperitone
0 ImagesCat. No.: HY-N21857CAS No.: 151006-27-8(4S, 6S)-4-Hydroxypiperitone is a monoterpene ketone found in the roots of Angelica Pubescens. (4S, 6S)-4-Hydroxypiperitone shows no obvious cytotoxic effect on RAW264.7 cells. (4S, 6S)-4-Hydroxypiperitone can be used in research related to inflammatory immunity and monoterpene biotransformation.
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Meliatoosenin Q
0 ImagesCat. No.: HY-N21590CAS No.: 1355997-09-9Meliatoosenin Q is a ring C-seco limonoid that can be found in the fruits of Melia toosendan. Meliatoosenin Q is used in studies related to limonoid chemistry, lung cancer, and leukemia.
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22α-Hydroxyoleanolic acid
0 ImagesCat. No.: HY-N17538CAS No.: 195874-52-322α-Hydroxyoleanolic acid (compound 11) is a triterpenoid found in the aerial parts of Schefflera kwangsiensis.
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Progoitrin potassium
0 ImagesCat. No.: HY-N10348ACAS No.: 21087-77-4Progoitrin potassium is an orally active glucosinolate. As the precursor of goitrin (HY-N0224A), an antithyroid compound, progoitrin releases goitrin via hydrolysis by myrosinase or gastrointestinal glucosidase. Progoitrin converts to goitrin in vivo and exerts antithyroid activity by inhibiting the accumulation of radioactive iodine in the thyroid gland. Progoitrin potassium can be used in the research of Graves' disease (thyrotoxicosis).
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Nujiangefolin A
0 ImagesCat. No.: HY-N13768CAS No.: 1393644-51-3Nujiangefolin A is a natural phenolic compound.
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Chlorcyclamide
0 ImagesCat. No.: HY-171845CAS No.: 19523-45-6Chlorcyclamide is a class of sulfonamide that can be used for the study of diabetes.
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Stelleranoid B
0 ImagesCat. No.: HY-N17201CAS No.: 2957870-90-3Stelleranoid B is a natural flavonoid.
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Trollisin I
0 ImagesCat. No.: HY-N21544CAS No.: 911063-04-2Trollisin I is a flavonoid C-glycoside present in the flowers of Trollius chinensis, and it exhibits no significant activity against influenza A and influenza B viruses.
