Progoitrin potassium
Progoitrin potassium is an orally active glucosinolate. As the precursor of goitrin (HY-N0224A), an antithyroid compound, progoitrin releases goitrin via hydrolysis by myrosinase or gastrointestinal glucosidase. Progoitrin converts to goitrin in vivo and exerts antithyroid activity by inhibiting the accumulation of radioactive iodine in the thyroid gland. Progoitrin potassium can be used in the research of Graves' disease (thyrotoxicosis).
For research use only. We do not sell to patients.
- CAS No.: 21087-77-4
- Formula: C11H18KNO10S2
- Molecular Weight:427.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Potassium progoitrin (1.4 μmol/g; 5-60 min at 150-200 °C) shows the lowest thermal stability in pH 9.0 phosphate buffer and undergoes thermal degradation to produce volatile flavor compounds[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Holtzman rats (male, 100-120 gm)[3]
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Dosage:20 mg; 200 mg; 300 mg; 625 mg; 1000 mg
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Administration:p.o.; s.c.; i.p.; 1 to 23.5 hours before I131 injection
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Result:Reduced thyroidal I131 uptake.
Chemical Information
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CAS No. 21087-77-4
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Molecular Weight 427.49
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Formula C11H18KNO10S2
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SMILES
C=C[C@H](O)C/C(S[C@@H]1O[C@@H]([C@H]([C@@H]([C@H]1O)O)O)CO)=N/OS(=O)(O[K])=O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[2]. Collett MG, et al. Hepatotoxicity of Two Progoitrin-Derived Nitriles in New Zealand White Rabbits. Toxins. 2020 Nov 02;12(11):695. [Content Brief]
[3]. GREER MA, et al. Antithyroid activity elicited by the ingestion of pure progoitrin, a naturally occurring thioglycoside of the turnip family. J Clin Invest. 1959 Sep;38(9):1465-74. [Content Brief]
[4]. Liu Z, et al. Reducing progoitrin and enriching glucoraphanin in Brassica napus seeds through silencing of the GSL-ALK gene family. Plant molecular biology. 2012 May;79(1-2):179-89. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Progoitrin potassium Related Classifications
HY-N10348A Related Classifications
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