Drug Derivative
Drug derivative
Drug derivatives are derived from parent compounds. They replace or add atoms and groups through chemical reactions to optimize the various properties of the parent compound and reduce side effects. The application of drug derivatives provides a diverse compound library for drug research and development and accelerates the discovery of new drugs. For example, urea derivatives Glibenclamide can prolong the blood sugar-lowering effect of anti-diabetic drugs.
References:
- [1]. Vardanyan RS, et al. Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications. Future Med Chem. 2014 Mar;6(4):385-412.x
- [2]. Ghosh AK, et al. Urea Derivatives in Modern Drug Discovery and Medicinal Chemistry. J Med Chem. 2020 Mar 26;63(6):2751-2788.x
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Drug Derivative Related Products (4022)
Related Products (4022)
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Schindilactone E
0 ImagesCat. No.: HY-N7997CAS No.: 1033288-86-6Schindilactone E is a natural product that can be found in Schisandra chinensis?(Turcz.) Baill..
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(4S, 6S)-4-Hydroxypiperitone
0 ImagesCat. No.: HY-N21857CAS No.: 151006-27-8(4S, 6S)-4-Hydroxypiperitone is a monoterpene ketone found in the roots of Angelica Pubescens. (4S, 6S)-4-Hydroxypiperitone shows no obvious cytotoxic effect on RAW264.7 cells. (4S, 6S)-4-Hydroxypiperitone can be used in research related to inflammatory immunity and monoterpene biotransformation.
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Meliatoosenin Q
0 ImagesCat. No.: HY-N21590CAS No.: 1355997-09-9Meliatoosenin Q is a ring C-seco limonoid that can be found in the fruits of Melia toosendan. Meliatoosenin Q is used in studies related to limonoid chemistry, lung cancer, and leukemia.
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22α-Hydroxyoleanolic acid
0 ImagesCat. No.: HY-N17538CAS No.: 195874-52-322α-Hydroxyoleanolic acid (compound 11) is a triterpenoid found in the aerial parts of Schefflera kwangsiensis.
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Progoitrin potassium
0 ImagesCat. No.: HY-N10348ACAS No.: 21087-77-4Progoitrin potassium is an orally active glucosinolate. As the precursor of goitrin (HY-N0224A), an antithyroid compound, progoitrin releases goitrin via hydrolysis by myrosinase or gastrointestinal glucosidase. Progoitrin converts to goitrin in vivo and exerts antithyroid activity by inhibiting the accumulation of radioactive iodine in the thyroid gland. Progoitrin potassium can be used in the research of Graves' disease (thyrotoxicosis).
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Nujiangefolin A
0 ImagesCat. No.: HY-N13768CAS No.: 1393644-51-3Nujiangefolin A is a natural phenolic compound.
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Chlorcyclamide
0 ImagesCat. No.: HY-171845CAS No.: 19523-45-6Chlorcyclamide is a class of sulfonamide that can be used for the study of diabetes.
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Stelleranoid B
0 ImagesCat. No.: HY-N17201CAS No.: 2957870-90-3Stelleranoid B is a natural flavonoid.
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Trollisin I
0 ImagesCat. No.: HY-N21544CAS No.: 911063-04-2Trollisin I is a flavonoid C-glycoside present in the flowers of Trollius chinensis, and it exhibits no significant activity against influenza A and influenza B viruses.
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Kelletinin A
0 ImagesCat. No.: HY-125054CAS No.: 112727-22-7Synonyms: BuccinulinKelletinin A is an active compound.
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Org-9768
0 ImagesCat. No.: HY-W223348CAS No.: 759424-59-4Org-9768 (Compound (2-methyl-2,3-dihydro-1H-inden-2-yl)methanamine) is a drug intermediate for synthesizing the mitochondrial permeability transition pore (mPTP) inhibitor. Org-9768 can be used for the researches of neurological and cardiovascular disease, such as Parkinson's disease.
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AF 698
0 ImagesCat. No.: HY-129406CAS No.: 82958-11-0AF 698 is a phthalate derivative of Apovincamine (HY-135743) that can be used as a peripheral vasodilator with selective vasomotor effects on cerebral microvascular circulation. AF 698 has better vasodilator effect than Vincamine (HY-B1021), but there is no significant difference in the protective effect of the two drugs against hypobaric hypoxia-induced lethality in mice.
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YM-08050
0 ImagesCat. No.: HY-123332CAS No.: 73328-60-6
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TH301
0 ImagesCat. No.: HY-134192CAS No.: 450338-32-6TH301 is a Phenylpyrazole derivative. TH301 selectively stabilize CRY2. TH301 dose-dependently prolongs circadian period.
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CB 966
0 ImagesCat. No.: HY-117638CAS No.: 128312-71-0CB 966 a Vitamin D3 (HY-15398) analogue, is an immunosuppressant. CB 966 delays rejection of allogeneic skin grafts in mice. CB 966 moderately increases serum calcium levels. CB 966 can be used for the research of allogeneic skin graft rejection.
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cis-LY393053
0 ImagesCat. No.: HY-123253CAS No.: 394735-81-0cis-LY393053 is an active compound.
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Antifungal agent 180
0 ImagesCat. No.: HY-189372CAS No.: 3117572-66-1Antifungal agent 180 is a pyrazole-oxadiazole-linked 1,2,4-triazole derivative and a broad-spectrum antifungal agent. Antifungal agent 180 disrupts fungal cellular homeostasis through multiple pathways, damaging the integrity of fungal hyphal cell membranes, increasing membrane permeability, and causing leakage of intracellular nucleic acids and proteins; it induces hyphal shrinkage, collapse, and organelle disintegration; and it causes widespread dysregulation of sterol/lipid metabolism, carbohydrate utilization, mitochondrial respiration, and stress response pathways at both the transcriptomic and proteomic levels. Antifungal agent 180 exhibits protective and curative efficacy against rice blast in vivo. Antifungal agent 180 can be used in research on rice blast and gray mold.
