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  3. Drug Derivative
  4. CB 966

CB 966 a Vitamin D3 (HY-15398) analogue, is an immunosuppressant. CB 966 delays rejection of allogeneic skin grafts in mice. CB 966 moderately increases serum calcium levels. CB 966 can be used for the research of allogeneic skin graft rejection.

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CB 966

CB 966 Chemical Structure

CAS No. : 128312-71-0

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Description

CB 966 a Vitamin D3 (HY-15398) analogue, is an immunosuppressant. CB 966 delays rejection of allogeneic skin grafts in mice. CB 966 moderately increases serum calcium levels. CB 966 can be used for the research of allogeneic skin graft rejection[1].

In Vivo

CB 966 (0.2-0.4 μg/kg; i.p.; daily; until rejection) significantly prolongs skin allograft survival in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male CBA (H-2k) mice (2-3 months) ransplanted with skin from the tails of C57Bl/6 (H-2ᵇ) mice[1]
Dosage: 0.2; 0.4 μg/kg
Administration: i.p.; daily; until rejection
Result: Prolonged mean skin allograft survival time to 14.3 days at 0.2 μg/kg.
Prolonged mean skin allograft survival time to 18.7 days at 0.4 μg/kg.
Produced statistically significant immunosuppressive effect compared to vehicle-treated controls (mean survival time 10.3 days).
Raised serum calcium levels moderately, measured on the day of rejection.
Molecular Weight

458.73

Formula

C30H50O3
CAS No.
SMILES

C[C@@]12[C@](\C(=C\C=C\3/C(=C)[C@@H](O)C[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](CCCCC(CC)(CC)O)C)[H])[H]
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Room temperature in continental US; may vary elsewhere.
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CB 966 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CB 966128312-71-0CB966CB-966Drug DerivativeDrug derivativeimmunosuppressantserum calciumskin allograft survivalcalcaemic agentallogeneic skin graft rejection1,25-dihydroxyvitamin D3allogeneic skin graftsmiceInhibitorinhibitorinhibit

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HY-117638
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