CB 966
CB 966 a Vitamin D3 (HY-15398) analogue, is an immunosuppressant. CB 966 delays rejection of allogeneic skin grafts in mice. CB 966 moderately increases serum calcium levels. CB 966 can be used for the research of allogeneic skin graft rejection.
For research use only. We do not sell to patients.
- CAS No.: 128312-71-0
- Formula: C30H50O3
- Molecular Weight:458.73
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Male CBA (H-2k) mice (2-3 months) ransplanted with skin from the tails of C57Bl/6 (H-2ᵇ) mice[1]
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Dosage:0.2; 0.4 μg/kg
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Administration:i.p.; daily; until rejection
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Result:Prolonged mean skin allograft survival time to 14.3 days at 0.2 μg/kg.
Prolonged mean skin allograft survival time to 18.7 days at 0.4 μg/kg.
Produced statistically significant immunosuppressive effect compared to vehicle-treated controls (mean survival time 10.3 days).
Raised serum calcium levels moderately, measured on the day of rejection.
Chemical Information
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CAS No. 128312-71-0
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Molecular Weight 458.73
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Formula C30H50O3
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SMILES
C[C@@]12[C@](\C(=C\C=C\3/C(=C)[C@@H](O)C[C@H](O)C3)\CCC1)(CC[C@@]2([C@@H](CCCCC(CC)(CC)O)C)[H])[H]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CB 966 Related Classifications
HY-117638 Related Classifications
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