2. Signaling Pathways
  3. PROTAC
  4. Hsp-targeting Chimeras
  5. Hsp70-targeting Chimeras Isoform

Hsp70-targeting Chimeras

Hsp70TACs

Hsp70-targeting Chimeras (Hsp70TACs) is a small-molecule, Hsp70-based targeted protein degradation platform. Hsp70TACs leverage the chaperone function of Hsp70 by conjugating a ligand for the protein of interest (POI) with an Hsp70 inhibitor, thereby mediating protein degradation via both the ubiquitin-proteasome system and the endosomal-lysosomal pathway.

Hsp70-targeting Chimeras Related Products (1):

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-182958
    Hsp70TAC BRD4 Degrader-1
    Hsp70TAC BRD4 Degrader-1 is a degrader targeting BRD4, with a KD value of 0.22 μM. Hsp70TAC BRD4 Degrader-1 forms a ternary complex with Hsp70 (KD: 5.13 μM), and specifically and efficiently degrades intracellular BRD4 via the ubiquitin-proteasome pathway. Hsp70TAC BRD4 Degrader-1 exhibits potent anti-tumor proliferative activity. Hsp70TAC BRD4 Degrader-1 can be used in studies related to triple-negative breast cancer and glioblastoma multiforme. (Pink: BRD4 ligand (HY-78695); Blue: HSP70 ligand (HY-182979); Black: linker (HY-B0236)).
    Hsp70TAC BRD4 Degrader-1