Lats2
Large tumor suppressor kinase 2 (LATS2) is a core serine/threonine kinase of the Hippo signaling pathway that restricts cell proliferation and supports tumor suppression through phosphorylation-dependent inhibition of the transcriptional coactivators YAP and TAZ, thereby regulating organ size, cell survival, and apoptosis[1][2]. Mechanistically, LATS2 functions downstream of the Hippo kinase cascade and serves as a major effector that converts upstream growth-suppressive signals into transcriptional repression of YAP/TAZ-dependent programs[1][2]. Beyond canonical Hippo signaling, LATS2 contributes to genomic stability, centrosome regulation, mitotic fidelity, and cell-cycle control, linking growth regulation with maintenance of cellular integrity[1][3]. LATS2 also interacts functionally with the p53 tumor suppressor network, where it contributes to p53 stabilization and activation, establishing a positive regulatory connection between the Hippo and p53 pathways during cellular stress responses and tumor suppression[1][4]. In disease contexts, reduced LATS2 expression has been reported in multiple cancers, and experimental studies support its role as a tumor suppressor whose loss can facilitate malignant progression[1][5]. Compared with the closely related isoform LATS1, LATS2 exhibits distinct biological functions and tissue-specific activities despite substantial structural similarity, indicating nonredundant roles in tumor biology and stress-response pathways[1][5]. In experimental models, LATS2 has been shown to regulate DNA damage responses through direct inhibition of c-Abl kinase activity, thereby influencing apoptosis decisions following genotoxic stress and providing a useful framework for investigating Hippo pathway-mediated cell fate regulation[6].
References:
- [1]. Khalili M, et al. Underserved Does Not Mean Undeserved: Unfurling the HCV Care in the Safety Net. Dig Dis Sci. 2018 Dec;63(12):3250-3252. [Content Brief]
- [2]. Reuven N, et al. The Hippo pathway kinase Lats2 prevents DNA damage-induced apoptosis through inhibition of the tyrosine kinase c-Abl. Cell Death Differ. 2013 Oct;20(10):1330-40. [Content Brief]
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Lats2 관련 제품 (6)
관련 제품 (6)
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TRULI
0 ImagesSynonyms: Lats-IN-1TRULI (Lats-IN-1) is a potent and ATP-competitive inhibitor of Lats1 and Lats2 kinases. TRULI promotes Yap-dependent proliferation in postmitotic mammalian tissues.
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GA-017
0 ImagesGA-017 is a potent and selective LATS1 and LATS2 (large tumor suppressor kinase 1/2) inhibitor, with IC50 values of 4.10 and 3.92 nM, respectively. GA-017 is an activator of cell proliferation. GA-017 promotes YAP/TAZ activation and nuclear translocation. GA-017 promotes cell growth under 3D culture conditions. GA-017 enhances the ex vivo formation of mouse intestinal organoids.
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VT02956
0 ImagesVT02956 is a LATS inhibitor (IC50: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids. VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Cardiomyocyte proliferation promoting agent-1
0 ImagesSynonyms: (E/Z)-GA-002Cardiomyocyte proliferation promoting agent-1 ((E/Z)-GA-002), which is an E/Z mixture, is a cardiomyocyte proliferation promoter. GA-002 (single E configuration) is a kinase inhibitor for LATS1 and LATS2, with its IC50 values being 3.93 nM and 3.87 nM respectively. GA-002 can induce the expression of genes regulated by the Hippo pathway, inhibit the phosphorylation of YAP/TAZ, and induce the nuclear translocation of YAP.
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LATS1/2-IN-1
0 ImagesCat. No.: HY-175649CAS No.: 3024011-99-9LATS1/2-IN-1 is a potent and selective LATS1 and LATS2 inhibitor. LATS1/2-IN-1 exhibits potent inhibitory activity against LATS1 and LATS2 with IC50 values of 4.4 nM and 5.5 nM as determined via r33P functional assay. LATS1/2-IN-1 displays cellular IC50 values of 136 nM for LATS1 and 36.0 nM for LATS2 as determined via NanoBRET assay. LATS1/2-IN-1 reduces phosphorylation of YAP1 in mouse liver. LATS1/2-IN-1 demonstrates wound healing activity in HT-1080 scratch assay and in vivo SKH1 mouse punch biopsy model. LATS1/2-IN-1 can be used for the study of regenerative medicine indications such as wound healing.
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VT02956 hydrochloride
0 ImagesCat. No.: HY-147165AVT02956 is a LATS inhibitor (IC50: 0.76 nM for LATS1, 0.52 nM for LATS2). VT02956 targets the Hippo pathway. VT02956 inhibits ESR1 expression and growth of ER+ breast cancer cell lines and patient-derived tumor organoids. VT02956 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
