3024011-79-5
Chemical Structure
NCGC-023
- CAS No.: 3024011-79-5
- Formula:C26H32FN3O3S
- Molecular Weight:485.61
InChIKey: SFZPKHFROINYFO-JSCPRHNGSA-N
SMILES: C[C@H]1CN(C[C@H]([C@@]1(C2=CC=C(C=C2C)C3=C4C(F)=CNC4=NC=C3)O)C)C5CCS(=O)(CC5)=O
Biological Activity: NCGC-023 is a LATS1/2 inhibitor. NCGC-023 selectively inhibits LATS1/2, an upstream regulator of Yap in the Hippo signaling pathway, increases the expression of active Yap protein, activates Yap-dependent signaling pathways, triggers non-Yap-dependent metallothionein-mediated heavy metal responses, and upregulates IL-33-related regenerative responses. NCGC-023 can be used in studies related to gastrointestinal acute radiation syndrome (GI-ARS)[1][2].
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NCGC-023 | NCGC-023 is a LATS1/2 inhibitor. NCGC-023 selectively inhibits LATS1/2, an upstream regulator of Yap in the Hippo signaling pathway, increases the expression of active Yap protein, activates Yap-dependent signaling pathways, triggers non-Yap-dependent metallothionein-mediated heavy metal responses, and upregulates IL-33-related regenerative responses. NCGC-023 can be used in studies related to gastrointestinal acute radiation syndrome (GI-ARS). | |||||||||||||||||||||
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- [1]. Driver LM, et al. Prophylactic inhibition of LATS1/2 before high-dose irradiation promotes the regeneration of the damaged intestinal epithelium. NPJ Regenerative medicine. 2026 Jul 20.
- [2]. Driver LM. Investigating the cellular responses and mitigation of injury in the small intestinal epithelia after high dose radiation [dissertation]. Durham (NC): Duke University; 2026.
Keywords
