mAChR
Muscarinic acetylcholine receptor
mAChRs (muscarinic acetylcholine receptors) are acetylcholine receptors that form G protein-receptor complexes in the cell membranes of certainneurons and other cells. They play several roles, including acting as the main end-receptor stimulated by acetylcholine released from postganglionic fibersin the parasympathetic nervous system. mAChRs are named as such because they are more sensitive to muscarine than to nicotine. Their counterparts are nicotinic acetylcholine receptors (nAChRs), receptor ion channels that are also important in the autonomic nervous system. Many drugs and other substances (for example pilocarpineand scopolamine) manipulate these two distinct receptors by acting as selective agonists or antagonists. Acetylcholine (ACh) is a neurotransmitter found extensively in the brain and the autonomic ganglia.
mAChR Isoform Specific Products
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mAChR Inhibitors
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mAChR Agonists
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mAChR Antagonists
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mAChR Activators
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mAChR Modulators
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mAChR Inducer
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mAChR Controls
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mAChR Ligands
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mAChR Related Products (718)
Related Products (718)
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Antibodies (2)
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mAChR Isoform Comparison
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(Rac)-5-Hydroxymethyl Tolterodine-d14
0 ImagesCat. No.: HY-76570SCAS No.: 1185071-13-9Synonyms: (Rac)-Desfesoterodine-d14; (Rac)-PNU-200577-d14(Rac)-5-Hydroxymethyl Tolterodine-d14 is the deuterium labeled (Rac)-5-Hydroxymethyl Tolterodine. (Rac)-5-Hydroxymethyl Tolterodine ((Rac)-Desfesoterodine), an active metabolite of Tolterodine, is a mAChR antagonist (Ki values of 2.3 nM, 2 nM, 2.5 nM, 2.8 nM, and 2.9 nM for M1, M2, M3, M4, and M5 receptors, respectively). (Rac)-5-Hydroxymethyl Tolterodine can be used for overactive bladder research.
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TD-6301
0 ImagesCat. No.: HY-171843CAS No.: 690999-15-6TD-6301 is a bladder-selective M2/4 muscarinic receptor antagonist. TD-6301 binds to and blocks M2/4 muscarinic receptors with high selectivity, especially human M2 receptors with strong affinity (Ki = 0.36 nM). TD-6301 inhibits volume-induced bladder contractions (ID50 = 0.075 mg/kg). TD-6301 can be used in the research of overactive bladder.
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Pargeverine hydrochloride
0 ImagesCat. No.: HY-W742955CAS No.: 2765-97-1Pargeverine hydrochloride is an antispasmodic opioid alkaloid. Pargeverine hydrochloride has a moderate and non-selective blockade of muscarinic cholinergic fibers. Pargeverine hydrochloride can be used in the research of painful spasms.
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RCC-36 hydrochloride
0 ImagesCat. No.: HY-182599CAS No.: 129927-37-3RCC-36 hydrochloride is an L-type calcium channel inhibitor and competitive muscarinic receptor antagonist. RCC-36 hydrochloride inhibits L-type calcium currents in voltage- and concentration-dependent fashion with no effect on cardiac K+ currents. RCC-36 hydrochloride suppresses maximum acetylcholine-induced contractile responses, inhibits detrusor muscle contractions induced by potassium chloride, calcium chloride, and electric field stimulation, including atropine-resistant contractions. RCC-36 hydrochloride can be used for the research of urinary frequency, urinary incontinence, and bladder overactivity.
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LY320135
0 ImagesCat. No.: HY-W011040CAS No.: 176977-56-3LY320135 is a potent and selective antagonist of CB1 receptor, with a Ki of 141 nM. LY320135 also binds to 5-HT2 and muscarinic receptors with Kis of 6.4 μM and 2.1 μM, respectively. LY320135 exhibits neuroprotective effect.
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Batefenterol Succinate
0 ImagesCat. No.: HY-12980ACAS No.: 945905-37-3Synonyms: GSK961081 Succinate; TD-5959 SuccinateBatefenterol Succinate (GSK961081 Succinate) is a first-of-its-kind inhaled bifunctional bronchodilator with smooth muscle relaxant properties. The activities of Batefenterol Succinate include acting as a smooth muscle parasympathetic antagonist and a beta2-adrenoceptor agonist. Batefenterol Succinate is used to improve respiratory function, especially in patients with chronic obstructive pulmonary disease (COPD).
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VU6016235
0 ImagesCat. No.: HY-169178CAS No.: 2344787-70-6VU6016235 is a highly selective, orally available, positive allosteric modulator of the M4 mAChR with in vivo inhibitory potency in animal models of psychosis..
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Telenzepine
0 ImagesCat. No.: HY-B1789CAS No.: 80880-90-6Telenzepine is an antimuscarinic agent with Kis of 0.94 nM (M1 mAChR) and 17.8 nM (M2 mAChR) binding to muscarinic receptors. Telenzepine effectively blocks synaptic transmission promoted by muscarinic or M1 receptor agonists. Thus, Telenzepine can reduce the amplitude of extracellular slow excitatory postsynaptic potentials (EC50=38 nM) and slow inhibitory postsynaptic potentials (EC50=253 nM).
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Desalkylquazepam
0 ImagesCat. No.: HY-W664824CAS No.: 1645-32-5Synonyms: N-DesmethylquazepamDesalkylquazepam (Compound 23; N-Desmethylquazepam) is a precursor in the synthesis of triazolobenzodiazepines. Desalkylquazepam is a mAChR modulator (EC 50 = 0.317 µM).
![[D-Trp7,9,10]-Substance P TFA](https://file.medchemexpress.com/product_pic/hy-p1375a.gif "Click to View [D-Trp7,9,10]-Substance P TFA Product Detail")
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rel-Biperiden EP impurity A-d5
0 ImagesCat. No.: HY-13204S2rel-Biperiden EP impurity A-d5 is deuterium labeled Biperiden (hydrochloride).
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VU6002703
0 ImagesCat. No.: HY-171981CAS No.: 1934241-32-3VU6002703 (Compound 17) is a BBB-penetrable M4 mAChR positive allosteric modulator (PAM) with an EC50 of 0.6 μM for hM4. VU6002703 can be used for neuropsychiatric and rare genetic CNS disorders research.
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Solifenacin D5 hydrochloride
0 ImagesCat. No.: HY-135329CAS No.: 1426174-05-1Solifenacin D5 hydrochloride is a deuterium labeled Solifenacin hydrochloride. Solifenacin hydrochloride is a muscarinic receptor antagonist with pKis of 7.6, 6.9 and 8.0 for M1, M2 and M3 receptors, respectively.
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VU6007678
0 ImagesCat. No.: HY-123778CAS No.: 2222737-15-5VU6007678 is a CNS-penetrant muscarinic acetylcholine receptor (mAChR) modulator. VU6007678 potentiates acetylcholine-mediated signaling at human M1, M3, M5 and rat M1, M3, M4, M5 muscarinic acetylcholine receptors. VU6007678 is applicable to research related to Alzheimer's disease, schizophrenia, and ischemic stroke.
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Bibn 140
0 ImagesCat. No.: HY-117966CAS No.: 145301-79-7Bibn 140 is a pyridine derivative substituted with a benzene ring, which has high affinity (Ki: 12 nM) and selectivity for M2 mAChR receptors over M1 receptors.
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Promethazine-d4
0 ImagesCat. No.: HY-B1296S1CAS No.: 1173147-64-2Synonyms: (±)-Promethazine-d4; N,N-dimethyl-1-phenothiazin-10-yl-propan-2-amine-d4Promethazine-d4 is a deuterated-labeled promethazine (HY-B0781). Promethazine is an orally active H1 receptor and mAChR antagonist with antihistamine (H1), sedative, antiemetic, anticholinergic, and anti-motion sickness properties.
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Milameline hydrochloride
0 ImagesCat. No.: HY-107650CAS No.: 139886-04-7Synonyms: CI 979 hydrochloride; RU 35926 hydrochlorideMilameline (CI 979; RU35926) hydrochloride is a nonselective, partical and orally active muscarinic receptor agonist that improves cognition. Milameline hydrochloride has equal affinity for different subtypes of human muscarinic receptors with IC50 of 1.3 µM for M1-, 1.1 µM for M2-, 1.5 µM for M3-, and 1.9 µM for M4-muscarinic receptors. Milameline hydrochloride has a higher affinity for sites [3H]CMD (IC50 = 20 nM), than [3H]QNB, (IC50 = 3059 nM). Milameline hydrochloride produces both central and peripheral cholinergic effects and reverses the cognitive deficits induced by Scopolamine (HY-N0296). Milameline hydrochloride can be used for the study of Alzheimer’s Disease.
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(S)-Vamicamide
0 ImagesCat. No.: HY-U00079BCAS No.: 151851-72-8Synonyms: (S)-FK-176(S)-Vamicamide ((S)-FK-176) is an anticholinergic compound.
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Succinylcholine iodide
0 ImagesSuccinylcholine iodide (Suxamethonium iodide) is a depolarizing neuromuscular blocker with rapid onset and short duration of action. Succinylcholine iodide also acts as an agonist of the Acetylcholine receptor. Succinylcholine iodide is used for emergency airway management.
