1645-32-5
1645-32-5
Chemical Structure
Desalkylquazepam
Synonym(s): N-Desmethylquazepam
- CAS No.: 1645-32-5
- Formula:C15H10ClFN2S
- Molecular Weight:304.77
IUPAC Name: 7-chloro-5-(2-fluorophenyl)-1,3-dihydro-2H-benzo[e][1,4]diazepine-2-thione
InChIKey: UAFWJQYZZIJGPD-UHFFFAOYSA-N
SMILES: FC1=CC=CC=C1C2=NCC(NC3=CC=C(C=C23)Cl)=S
Biological Activity: Desalkylquazepam (Compound 23; N-Desmethylquazepam) is a precursor in the synthesis of triazolobenzodiazepines[1]. Desalkylquazepam is a mAChR modulator (EC 50 = 0.317 µM)[2].
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Desalkylquazepam | Desalkylquazepam (Compound 23; N-Desmethylquazepam) is a precursor in the synthesis of triazolobenzodiazepines. Desalkylquazepam is a mAChR modulator (EC 50 = 0.317 µM). | |||||||||||||||||||||
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References
- [1]. Hester JB Jr, et al. 6-phenyl-4H-s-triazolo[4,3-a][1,4]benzodiazepines which have central nervous system depressant activity. J Med Chem. 1971 Nov;14(11):1078-81. [Content Brief]
- [2]. Flohr A, Hutter R, Mueller B, Bohnert C, Pellisson M, Schaffhauser H. Discovery of the first low-shift positive allosteric modulators for the muscarinic M1 receptor. Bioorg Med Chem Lett. 2017;27(24):5415-5419. [Content Brief]
Keywords
