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Cat. No.: HY-187713

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α-Glucosidase-IN-122

α-Glucosidase-IN-122 is an inhibitor of α-glucosidase (α-Glucosidase). α-Glucosidase-IN-122 regulates glucose and lipid metabolism through multiple pathways, including inhibition of α-glucosidase and lipase, and exertion of antioxidant activity, and enhances glucose consumption in insulin-resistant HepG2 cells. α-Glucosidase-IN-122 can be used in the research of type 2 diabetes.

For research use only. We do not sell to patients.

Formula: C₂₆H₁₈O₈
Molecular Weight:458.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

α-Glucosidase-IN-122 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
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Biological Activity

Description

IC₅₀ & Target

^[1]

α‑glucosidase

In Vitro

α-Glucosidase-IN-122 (compound 7F) at 50 μM inhibits purified α-glucosidase, with an inhibition rate of 24.04% under the condition of 50 μM^[1].
α-Glucosidase-IN-122 (compound 7f) exhibits a cytotoxicity IC₅₀ > 200 μM against HepG2 cells^[1].
α-Glucosidase-IN-122 (50 μM) inhibits purified lipase, with an inhibition rate of 26.04% at 50 μM^[1].
α-Glucosidase-IN-122 scavenges DPPH free radicals in a cell-free system, with an IC₅₀ value of 171.6 μM^[1].
α-Glucosidase-IN-122 (0.1-10 μM) enhances glucose consumption in glucosamine-induced insulin-resistant HepG2 cells; the increase rates of glucose consumption at 10, 1 and 0.1 μM are 58.67%, 53.21% and 38.38%, respectively, all higher than those of metformin at the same concentrations (27.21%, 19.34% and 8.90%)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 458.42
Formula C₂₆H₁₈O₈
SMILES

O=C(OC1=CC(OC(C2=CC=CC=C2)=CC3=O)=C3C(O)=C1O)/C=C/C4=C(OC(C)=O)C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Zhao X, et al. A Novel Series of Flavone-Cinnamic Acid Hybrid Derivatives as Hypoglycemic Agents: Design, Synthesis, and Activity Studies. Chemistry & biodiversity. 2026 Jul;23(7):e71501. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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